eIF4A2 targets developmental potency and histone H3. 3 transcripts for translational control of stem cell pluripotency

D Li, J Yang, X Huang, H Zhou, J Wang - Science Advances, 2022 - science.org
Translational control has emerged as a fundamental regulatory layer of proteome complexity
that governs cellular identity and functions. As initiation is the rate-limiting step of translation …

An RNAi screen of RNA helicases identifies eIF4A3 as a regulator of embryonic stem cell identity

D Li, J Yang, V Malik, Y Huang, X Huang… - Nucleic acids …, 2022 - academic.oup.com
RNA helicases are involved in multiple steps of RNA metabolism to direct their roles in gene
expression, yet their functions in pluripotency control remain largely unexplored. Starting …

Locus-Specific Isolation of the Nanog Chromatin Identifies Regulators Relevant to Pluripotency of Mouse Embryonic Stem Cells and Reprogramming of Somatic Cells

AK Burramsetty, K Nishimura, T Kishimoto… - International Journal of …, 2022 - mdpi.com
Pluripotency is a crucial feature of pluripotent stem cells, which are regulated by the core
pluripotency network consisting of key transcription factors and signaling molecules …

RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation

W Fan, X Li - Current Stem Cell Reports, 2024 - Springer
RNA-mediated glycolytic regulation in embryonic stem cells is important for their
maintenance and transitions between different stages of differentiation. Better understanding …

The RNA-binding protein CMSS1 promotes the progression of non-small cell lung cancer by regulating the telomerase protein subunit hTERT

W Gu, H Li, L Sun, Z Shen, Y Wang, X Hu, Y Wu, W Liu… - Life Sciences, 2025 - Elsevier
Aims High telomerase activity has been detected in over 85% of tumors, with the activation
of hTERT being the most crucial mechanism for re-establishing telomerase activity …

Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells

Y Chen, Y Chen, Q Li, H Liu, J Han, H Zhang, L Cheng… - Cell Reports, 2023 - cell.com
The RNA-binding protein Musashi-1 (MSI1) regulates the proliferation and differentiation of
adult stem cells. However, its role in embryonic stem cells (ESCs) and early embryonic …

Acoustic vibration promotes in vitro expansion of human embryonic stem cells

X Hu, H Duan, D Zou, C Dong, Y Wang… - American Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Objectives: This study aimed to investigate the effect of acoustic vibration on the pluripotency
of human embryonic stem cells (hESCs) and evaluate cell proliferation and self-renewal …

Regulation of mRNA Export by Key Signaling Pathways and its Implications for Embryonic Stem Cell Differentiation and Potency: A Systematic Review

V Shafi - 2024 - researchsquare.com
Objective: This study focuses on the regulatory role of mRNA export in embryonic stem cell
(ESC) potency and differentiation, vital processes for developmental biology. It investigates …

RBM47 is a critical regulator of mouse embryonic stem cell differentiation

PKM Shivalingappa, DK Singh, V Sharma… - Stem Cell Reviews and …, 2023 - Springer
RNA-binding proteins (RBPs) are pivotal for regulating gene expression as they are
involved in each step of RNA metabolism. Several RBPs are essential for viable growth and …

Identification the hub genes in HL-60 leukemia cells on decitabine through bioinformatics analysis

F Meng, L Li, Q Zheng - Clinical Medicine Insights, 2023 - medicineinsights.info
Objective: Aims to identification the hub genes in HL-60 acute myeloid leukemia cells
treated with decitabine, provide meaningful insights into the pathogenesis of AML. Methods …