Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

X Wei, Y Chen, X Jiang, M Peng, Y Liu, Y Mo, D Ren… - Molecular cancer, 2021 - Springer
Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process
found in many malignant tumors, and is different from the traditional angiogenetic process …

Underlying mechanisms for distant metastasis-molecular biology

E Pachmayr, C Treese, U Stein - Visceral medicine, 2017 - karger.com
Background: The formation of distant metastases constitutes a complex process with a
variety of different genes and pathways involved. To improve patient survival, it is necessary …

Long non-coding RNA MALAT1 promotes gastric cancer tumorigenicity and metastasis by regulating vasculogenic mimicry and angiogenesis

Y Li, Z Wu, J Yuan, L Sun, L Lin, N Huang, J Bin, Y Liao… - Cancer letters, 2017 - Elsevier
MALAT1 is an oncogenic long non-coding RNA that has been found to promote the
proliferation of many malignant cell types and non-malignant human umbilical vein …

The relationship between vasculogenic mimicry and epithelial‐mesenchymal transitions

Q Liu, L Qiao, N Liang, J Xie, J Zhang… - Journal of cellular …, 2016 - Wiley Online Library
Vasculogenic mimicry (VM) is a vascular‐like structure which can mimic the embryonic
vascular network pattern to nourish the tumour tissue. As a unique perfusion way, VM is …

Long noncoding RNA MALAT1 as a potential therapeutic target in osteosarcoma

X Cai, Y Liu, W Yang, Y Xia, C Yang… - Journal of …, 2016 - Wiley Online Library
Recent studies have revealed that long noncoding RNA metastasis‐associated lung
adenocarcinoma transcript 1 (MALAT1) plays an important role in the development of …

Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric …

J Xia, H Wang, H Huang, L Sun, S Dong, N Huang… - Cancer letters, 2016 - Elsevier
ORAI calcium release-activated calcium modulator 1 (Orai1)-and stromal interacting
molecule 1 (STIM1)-mediated store-operated Ca 2+ entry (SOCE) have been increasingly …

Molecular alterations of cancer cell and tumour microenvironment in metastatic gastric cancer

W Li, JMK Ng, CC Wong, EKW Ng, J Yu - Oncogene, 2018 - nature.com
The term metastasis is widely used to describe the endpoint of the process by which tumour
cells spread from the primary location to an anatomically distant site. Achieving successful …

Hypoxic induction of vasculogenic mimicry in hepatocellular carcinoma: role of HIF-1 α, RhoA/ROCK and Rac1/PAK signaling

JG Zhang, HM Zhou, X Zhang, W Mu, JN Hu, GL Liu… - BMC cancer, 2020 - Springer
Background Vasculogenic mimicry (VM), defined as a capability of aggressive tumor Cells to
mimic embryonic vasculogenic networks, caused poor prognosis in hepatocellular …

The twisted survivin connection to angiogenesis

C Sanhueza, S Wehinger, J Castillo Bennett… - Molecular cancer, 2015 - Springer
Survivin, a member of the inhibitor of apoptosis family of proteins (IAPs) that controls cell
division, apoptosis, metastasis and angiogenesis, is overexpressed in essentially all human …

Androgen receptor promotes renal cell carcinoma (RCC) vasculogenic mimicry (VM) via altering TWIST1 nonsense-mediated decay through lncRNA-TANAR

B You, Y Sun, J Luo, K Wang, Q Liu, R Fang, B Liu… - Oncogene, 2021 - nature.com
While the androgen receptor (AR) may influence the progression of clear cell renal cell
carcinoma (ccRCC), its role to impact vasculogenic mimicry (VM) to alter the ccRCC …