Burkitt lymphoma (BL) is an aggressive form of B cell lymphoma that can affect children and
adults. The study of BL led to the identification of the first recurrent chromosomal aberration …

The use of genomics is firmly established in clinical practice, resulting in innovations across
a wide range of disciplines such as genetic screening, rare disease diagnosis and …

Richter syndrome (RS) arising from chronic lymphocytic leukemia (CLL) exemplifies an
aggressive malignancy that develops from an indolent neoplasm. To decipher the genetics …

Third-generation sequencing can be used in human cancer genomics and epigenomic
research. Oxford Nanopore Technologies (ONT) recently released R10. 4 flow cell, which …

B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

In patients with chronic lymphocytic leukemia, Richter transformation (RT) reflects the
development of an aggressive lymphoma that is associated with poor response to …

The MYC transcription factor, encoded by the c‐MYC proto‐oncogene, is activated by
growth‐promoting signals, and is a key regulator of biosynthetic and metabolic pathways …

Richter's Transformation (RT) is a poorly understood and fatal progression of chronic
lymphocytic leukemia (CLL) manifesting histologically as diffuse large B-cell lymphoma …

Although the genetic landscape of chronic lymphocytic leukemia (CLL) has been broadly
profiled by large-scale sequencing studies performed over the past decade, the molecular …

Richter syndrome (RS) is the transformation of chronic lymphocytic leukemia (CLL) into
aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). We …