Malaria is a significant public health problem in more than 100 countries and causes an
estimated 200 million new infections every year. Despite the significant effort to eradicate …

Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Artemisinin derivatives are the most recent single drugs approved and introduced for public
antimalarial treatment. Although their recommended use is for treatment of Plasmodium …

Artemisinins were discovered to be highly effective antimalarial drugs shortly after the
isolation of the parent artemisinin in 1971 in China. These compounds combine potent …

Artemisinin-based combination therapy (ACT) is the recommended first-line treatment for
Plasmodium falciparum malaria. It has been suggested that the cytotoxic effect of artemisinin …

Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

The artemisinin derivatives, dihydroartemisinin (DHA), artesunate, atemether and arteether,
are currently used for treatment of malaria in artemisinin combination therapies (ACT) with …

Artemisinin and its derivatives are currently recommended as first-line antimalarials in
regions where Plasmodium falciparum is resistant to traditional drugs. The cytotoxic activity …

Malaria continues to be a potentially fatal threat to almost half of the world's population. In
light of this threat, the armory to fight this disease is rather limited. Resistance against the …