The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target
AN Barclay, TK Van den Berg - Annual review of immunology, 2014 - annualreviews.org
CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory
immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member …
immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member …
Functions and molecular mechanisms of the CD47–SIRPα signalling pathway
T Matozaki, Y Murata, H Okazawa, H Ohnishi - Trends in cell biology, 2009 - cell.com
Signal regulatory protein (SIRP) α, also known as SHPS-1 or SIRPA, is a transmembrane
protein that binds to the protein tyrosine phosphatases SHP-1 and SHP-2 through its …
protein that binds to the protein tyrosine phosphatases SHP-1 and SHP-2 through its …
CD47 protects synapses from excess microglia-mediated pruning during development
EK Lehrman, DK Wilton, EY Litvina, CA Welsh… - Neuron, 2018 - cell.com
Microglia regulate synaptic circuit remodeling and phagocytose synaptic material in the
healthy brain; however, the mechanisms directing microglia to engulf specific synapses and …
healthy brain; however, the mechanisms directing microglia to engulf specific synapses and …
The SIRP family of receptors and immune regulation
AN Barclay, MH Brown - Nature Reviews Immunology, 2006 - nature.com
The immune system must be highly regulated to obtain optimal immune responses for the
elimination of pathogens without causing undue side effects. This tight regulation involves …
elimination of pathogens without causing undue side effects. This tight regulation involves …
CD200 and membrane protein interactions in the control of myeloid cells
AN Barclay, GJ Wright, G Brooke, MH Brown - Trends in immunology, 2002 - cell.com
Abstract OX2 (now designated CD200) is a membrane protein expressed by a broad range
of cell types. It is the ligand for a receptor restricted to myeloid cells, with the potential to …
of cell types. It is the ligand for a receptor restricted to myeloid cells, with the potential to …
[HTML][HTML] The classical complement pathway mediates microglia-dependent remodeling of spinal motor circuits during development and in SMA
Movement is an essential behavior requiring the assembly and refinement of spinal motor
circuits. However, the mechanisms responsible for circuit refinement and synapse …
circuits. However, the mechanisms responsible for circuit refinement and synapse …
Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina
Microglia utilize their phagocytic activity to prune redundant synapses and refine neural
circuits during precise developmental periods. However, the neuronal signals that control …
circuits during precise developmental periods. However, the neuronal signals that control …
Synaptic adhesion molecules
Formation, differentiation and plasticity of synapses, the specialized cell–cell contacts
through which neurons communicate, all require interactions between pre-and post-synaptic …
through which neurons communicate, all require interactions between pre-and post-synaptic …
Microglia in neuronal plasticity: influence of stress
The central nervous system (CNS) has previously been regarded as an immune-privileged
site with the absence of immune cell responses but this dogma was not entirely true …
site with the absence of immune cell responses but this dogma was not entirely true …
Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept'of Alzheimer's disease or the yin and yang …
T Arendt - Progress in neurobiology, 2003 - Elsevier
Mental actions are based on the dynamic organization of neuronal networks. In particular,
phylogenetically young brain areas (eg, cortical associative circuits) involved in the …
phylogenetically young brain areas (eg, cortical associative circuits) involved in the …