The concept of allostery has evolved in the past century. In this Editorial, we briefly overview
the history of allostery, from the pre-allostery nomenclature era starting with the Bohr effect …

Recent advances in structural biology and computational techniques have revealed
allosteric mechanisms for an abundance of targets leading to the establishment of rational …

INTRODUCTION Enzymes possess extraordinary catalytic proficiency and specificity. These
properties ultimately derive from interactions not just between the active-site residues and …

Generative models emerge as promising candidates for novel sequence-data driven
approaches to protein design, and for the extraction of structural and functional information …

Activation heat capacity is emerging as a crucial factor in enzyme thermoadaptation, as
shown by the non-Arrhenius behaviour of many natural enzymes. However, its physical …

Understanding the pattern of epistasis—the non-independence of mutations—is critical for
relating genotype and phenotype. However, the combinatorial complexity of potential …

Protein function arises from a poorly understood pattern of energetic interactions between
amino acid residues. Sequence-based strategies for deducing this pattern have been …

Intrinsically disordered regions (IDRs) can function as autoregulators of folded enzymes to
which they are tethered. One example is the bacterial cell division protein FtsZ. This includes …

Mutations of the androgen receptor (AR) associated with prostate cancer and androgen
insensitivity syndrome may profoundly influence its structure, protein interaction network …

Mammalian circadian clocks are driven by a transcription/translation feedback loop
composed of positive regulators (CLOCK/BMAL1) and repressors (CRYPTOCHROME 1/2 …