Interorganellar contacts are increasingly recognized as central to the control of cellular
behavior. These contacts, which typically involve a small fraction of the endomembrane …

Mitochondrial network architecture plays a critical role in cellular physiology. Indeed,
alterations in the shape of mitochondria upon exposure to cellular stress can cause the …

Alantolactone (ALT), a sesquiterpene lactone component of Inula helenium, has been
reported to exert anticancer activity in various cancers. However, the cellular targets and …

Background Nobiletin is a natural polymethoxylated flavone that confers antioxidative, anti-
inflammatory and anti-apoptotic efficacies. However, the potential benefits of nobiletin …

The discovery of proteins regulating ER-mitochondria tethering including phosphofurin
acidic cluster sorting protein 2 (PACS-2) and mitofusin-2 has pushed contact sites between …

Mitochondria are important organelles of eukaryotic cells and involved in a variety of cellular
processes including oxidative phosphorylation for generating ATP, apoptosis, steroid …

Purpose Breast cancer is the most common malignancy among women across the globe.
Despite concerted efforts to improve the prevailing treatment modalities, the overall …

Ceramides are central intermediates of sphingolipid metabolism with dual roles as
mediators of cellular stress signaling and mitochondrial apoptosis. How ceramides exert …

Abstract The Steroidogenic Acute R egulatory Protein-related Lipid T ransfer (START)
domain is a~ 210 amino acid sequence that folds into an α/β helix-grip structure forming a …

Mitochondria synthesize select phospholipids but lack the machinery for synthesis of the
most abundant mitochondrial phospholipid, phosphatidylcholine (PC). Although the …