Phage lysins for intestinal microbiome modulation: current challenges and enabling techniques

I Pottie, R Vázquez Fernández, T Van de Wiele… - Gut …, 2024 - Taylor & Francis
The importance of the microbiota in the intestinal tract for human health has been
increasingly recognized. In this perspective, microbiome modulation, a targeted alteration of …

Engineered therapeutic proteins for sustained-release drug delivery systems

TTK Nguyen, KY Pham, S Yook - Acta Biomaterialia, 2023 - Elsevier
Proteins play a vital role in diverse biological processes in the human body, and protein
therapeutics have been applied to treat different diseases such as cancers, genetic …

Innovative probiotic Escherichia coli nissle 1917-derived outer membrane vesicles coupled microspheres demonstrate anti-inflammatory and barrier-enhancing …

L Han, XW Liu, WX Li, T Zang, ZP Li, Y Deng… - Chemical Engineering …, 2024 - Elsevier
Occurrence of inflammatory bowel disease (IBD) is increasing worldwide and has become a
global health threat. Nonetheless, the effective prevention and available treatment …

Tailoring the pore structure of iron oxide core@ stellate mesoporous silica shell nanocomposites: effects on MRI and magnetic hyperthermia properties and …

J Bizeau, J Journaux-Duclos, C Kiefer, B Freis… - Nanoscale, 2024 - pubs.rsc.org
Core–shell nanocomposites made of iron oxide core (IO NPs) coated with mesoporous silica
(MS) shells are promising theranostic agents. While the core is being used as an efficient …

Grafting of crown ether and cryptand macrocycles on large pore stellate mesoporous silica for sodium cation extraction

P Duenas-Ramirez, C Bertagnolli, R Weiss, J Bizeau… - Molecules, 2023 - mdpi.com
Regulation of the sodium cations level in the case of renal failure diseases is a very
challenging task for clinicians, and new pollutant extractors based on nanomaterials are …

Tuning the size and concentration of functional molecules coated onto mesoporous silica nanoparticles for efficient therapeutic protein delivery

P Esmaeilnejad-Ahranjani, SA Maboudi - Materials Today Communications, 2023 - Elsevier
In this work, the importance of the size and concentration of binding sites in mesoporous
nanostructures on their performance for protein delivery is reported. Various types of …

Powerful Protein Nanoreservoirs Based on Stellate Mesoporous Silica Embedded in Composite Hydrogels: From Burst Release to Retention

J Bizeau, M Rabineau, J Buisson… - Macromolecular …, 2024 - Wiley Online Library
In the biomaterials field, one major issue with hydrogels (HGs) loaded with active
therapeutics is the spontaneous leaking of the cargo occurring rapidly, usually over several …