Oxidative stress is considered a major contributor to etiology of both “normal” senescence
and severe pathologies with serious public health implications. Mitochondria generate …

Defective sperm function has been identified as the most common cause of infertility. The
objective of this study was to review recent findings on the effects of various antioxidants on …

Prxs (peroxiredoxins) are a family of proteins that are extremely effective at scavenging
peroxides. The Prxs exhibit a number of intriguing properties that distinguish them from …

Diverse functions of eukaryotic cells are optimized by organization of compatible chemistries
into distinct compartments defined by the structures of lipid-containing membranes …

Reactive oxygen species (ROS) function as intracellular signaling molecules in a diverse
range of biological processes. However, it is unclear how freely diffusible ROS dictate …

▪ Abstract New methods to measure thiol oxidation show that redox compartmentation
functions as a mechanism for specificity in redox signaling and oxidative stress. Redox …

Abstract Peroxiredoxin 5 (PRDX5) was the last member to be identified among the six
mammalian peroxiredoxins. It is also the unique atypical 2-Cys peroxiredoxin in mammals …

Despite intensive research on peroxisome biochemistry, the role of glutathione in
peroxisomal redox homeostasis has remained a matter of speculation for many years, and …

Peroxiredoxins (Prxs) are a family of multifunctional antioxidant thioredoxin-dependent
peroxidases that have been identified in a large variety of organisms. The major functions of …

Proteins with oxidizable thiols are essential to many functions of cell nuclei, including
transcription, chromatin stability, nuclear protein import and export, and DNA replication and …