Visceral smooth muscle is a crucial component of the walls of hollow organs like the gut,
bladder, and uterus. This specialized smooth muscle has unique properties that distinguish …

The Hsp90 molecular chaperone, along with a set of approximately 50 cochaperones,
mediates the folding and activation of hundreds of cellular proteins in an ATP-dependent …

Visceral myopathy is a life-threatening disease characterized by muscle weakness in the
bowel, bladder, and uterus. Mutations in smooth muscle γ-actin (ACTG2) are the most …

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome Overview - GeneReviews® -
NCBI Bookshelf US flag An official website of the United States government Here's how you …

Malignant glioma is the most frequent primary tumor of the central nervous system. PDCL3 is
a member of the phosducin-like protein family, and its imbalance has been shown to be …

Hirschsprung disease (HSCR) and Paediatric Intestinal Pseudo-obstruction (PIPO) comprise
two of the most recognized and severe disorders of gastrointestinal (GI) motility. HSCR is a …

Proper cellular proteostasis, essential for viability, requires a network of chaperones and
cochaperones. ATP-dependent chaperonin TRiC/CCT partners with cochaperones prefoldin …

Introduction Gastrointestinal (GI) motility disorders comprise a wide range of different
diseases affecting the structural or functional integrity of the GI neuromusculature. Their …

Abstract Megacystis-microcolon-hypoperistalsis-syndrome (MMIHS) is a rare and early-
onset congenital disease characterized by massive abdominal distension due to a large non …

Chronic intestinal pseudo-obstruction (CIPO) represents the most severe end of the
spectrum of gut motility disorders comprising a group of rare, heterogeneous, and disabling …