Although sinus node dysfunction (SND) and atrial arrhythmias frequently coexist and
interact, the putative mechanism linking the 2 remain unclear. Although SND is …

The sinoatrial node (SAN) is the normal pacemaker of the heart and SAN dysfunction (SND)
is common, but until recently the pathophysiology was incompletely understood. It was …

The human sinoatrial node (SAN) efficiently maintains heart rhythm even under adverse
conditions. However, the specific mechanisms involved in the human SAN's ability to …

Heart rhythm is initialized and controlled by the Sinoatrial Node (SAN), the primary
pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure …

Aims The aim of this study was to use human genetics to investigate the pathogenesis of
sick sinus syndrome (SSS) and the role of risk factors in its development. Methods and …

Heart failure (HF) is frequently accompanied with the sinoatrial node (SAN) dysfunction,
which causes tachy-brady arrhythmias and increased mortality. MicroRNA (miR) alterations …

Irreversible degeneration of the cardiac conduction system is a common disease that can
cause activity intolerance, fainting, and death. While electronic pacemakers provide effective …

Sinus node dysfunction (SND) encompasses a range of sinus node and/or atrial
electrophysiologic/arrhythmic disturbances with clinical consequences ranging from none or …

Sinoatrial node (SAN) disease mechanisms are poorly understood, and therapeutic options
are limited. Natriuretic peptide (s)(NP) are cardioprotective hormones whose effects can be …

The rhythmic and spontaneously generated electrical excitation that triggers the heartbeat
originates in the sinoatrial node (SAN). SAN automaticity has been thoroughly investigated …