Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Post-translational modification of histones provides an important regulatory platform for
processes such as gene transcription and DNA damage repair. It has become increasingly …

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) resets the
epigenome to an embryonic-like state. Vitamin C enhances the reprogramming process, but …

Abstract p16INK4a, located on chromosome 9p21. 3, is lost among a cluster of neighboring
tumor suppressor genes. Although it is classically known for its capacity to inhibit cyclin …

Polycomb group (PcG) proteins play important roles in repressing lineage-specific genes
and maintaining the undifferentiated state of mouse embryonic stem cells (mESCs) …

Histone modifications serve as regulatory marks that are instrumental for the control of
transcription and chromatin architecture. Strict regulation of gene expression patterns is …

Polycomb group (PcG) proteins are epigenetic repressors that are essential for the
transcriptional control of cell differentiation and development. PcG-mediated repression is …

The erasure of epigenetic modifications across the genome of somatic cells is an essential
requirement during their reprogramming into induced pluripotent stem cells (iPSCs). Vitamin …

Resistance of cancer cells to chemotherapeutics and emerging targeted drugs is a
devastating problem in the treatment of cancer patients. Multiple mechanisms contribute to …