Populations that experience severe stress may avoid extinction through adaptation by
natural selection. This process is called evolutionary rescue and has been studied under …

Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …

Antimicrobial pharmacodynamics is the discipline that integrates microbiology and
pharmacology, with the aim of linking a measure of drug exposure, relative to a measure of …

Background The rates of antibiotic resistance in Gram-negative bacteria are increasing. One
method to minimize resistance emergence may be optimization of antibiotic dosing …

Pharmacokinetic-pharmacodynamic (PKPD) modeling and simulation has evolved as an
important tool for rational drug development and drug use, where developed models …

Since the advent of the modern era of antimicrobial chemotherapy in the 1930s, animal
infection models have allowed for the in vivo evaluation of antimicrobial agents for the …

ABSTRACT In June 2017, the National Institute of Allergy and Infectious Diseases, part of
the National Institutes of Health, organized a workshop entitled “Pharmacokinetics …

The world of antibiotic drug discovery and development is driven by the necessity to
overcome antibiotic resistance in common Gram-positive and Gram-negative pathogens …

The mutant selection window hypothesis postulates that, for each antimicrobial-pathogen
combination, an antimicrobial concentration range exists in which selective amplification of …

Quinolones are one of the largest classes of antimicrobial agents used worldwide. This
review considers the quinolones that are available currently and used widely in Europe …