NADPH oxidase in brain injury and neurodegenerative disorders

MW Ma, J Wang, Q Zhang, R Wang… - Molecular …, 2017 - Springer
Oxidative stress is a common denominator in the pathology of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …

Microbial infections are a risk factor for neurodegenerative diseases

SK Lotz, BM Blackhurst, KL Reagin… - Frontiers in Cellular …, 2021 - frontiersin.org
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, comprise a family of disorders characterized by progressive …

[HTML][HTML] Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis

D Patoli, F Mignotte, V Deckert… - The Journal of …, 2020 - Am Soc Clin Investig
Mitochondria have emerged as key actors of innate and adaptive immunity. Mitophagy has a
pivotal role in cell homeostasis, but its contribution to macrophage functions and host …

Antibacterial effects of low-temperature plasma generated by atmospheric-pressure plasma jet are mediated by reactive oxygen species

MKJ Nicol, TR Brubaker, BJ Honish, AN Simmons… - Scientific reports, 2020 - nature.com
Emergence and spread of antibiotic resistance calls for development of non-chemical
treatment options for bacterial infections. Plasma medicine applies low-temperature plasma …

NADPH oxidases in Parkinson's disease: a systematic review

K Belarbi, E Cuvelier, A Destée, B Gressier… - Molecular …, 2017 - Springer
Parkinson's disease (PD) is a progressive movement neurodegenerative disease
associated with a loss of dopaminergic neurons in the substantia nigra of the brain …

Autophagy primes neutrophils for neutrophil extracellular trap formation during sepsis

SY Park, S Shrestha, YJ Youn, JK Kim… - American journal of …, 2017 - atsjournals.org
Rationale: Neutrophils are key effectors in the host's immune response to sepsis. Excessive
stimulation or dysregulated neutrophil functions are believed to be responsible for sepsis …

The impact of the systemic inflammatory response on hepatic bacterial elimination in experimental abdominal sepsis

K Hanslin, J Sjölin, P Skorup, F Wilske… - Intensive Care Medicine …, 2019 - Springer
Background Bacterial translocation from the gut has been suggested to induce a systemic
inflammatory response syndrome (SIRS) and organ dysfunction. The liver has a pivotal role …

PARK7 promotes repair in early steroid-induced osteonecrosis of the femoral head by enhancing resistance to stress-induced apoptosis in bone marrow …

F Zhang, Y Yan, W Peng, L Wang, T Wang, Z Xie… - Cell death & …, 2021 - nature.com
Novel therapies for the treatment of early steroid-induced osteonecrosis of the femoral head
(SONFH) are urgently needed in orthopedics. Transplantation of bone marrow …

Role of DJ-1 in immune and inflammatory diseases

L Zhang, J Wang, J Wang, B Yang, Q He… - Frontiers in …, 2020 - frontiersin.org
The DJ-1 protein, known as an oxidative stress sensor, participates in the onset of oxidative
stress-related diseases such as cancer, neurodegenerative disorders, type 2 diabetes, and …

PARK7/DJ-1 in microglia: implications in Parkinson's disease and relevance as a therapeutic target

F Lind-Holm Mogensen, A Scafidi, A Poli… - Journal of …, 2023 - Springer
Microglia are the immune effector cells of the brain playing critical roles in immune
surveillance and neuroprotection in healthy conditions, while they can sustain …