Recognition of molecular diversity of cell surface proteomes in disease is essential for the
development of targeted therapies. Progress in targeted therapeutics requires establishing …

Introduction The finding of antinuclear antibody (ANA) positivity in a healthy individual is
usually of unknown significance and in most cases is benign. However, a subset of such …

BACKGROUND Weakly virulent environmental mycobacteria (EM) can cause severe
disease in HLA-DRB1* 15: 02 or 16: 02 adults harboring neutralizing anti-IFN-γ …

Antinuclear antibodies (ANA) are primarily significant in the diagnosis of systemic
connective tissue diseases. The relationship between their occurrence in allergic diseases …

Introduction Pediatric systemic lupus erythematosus (pSLE) patients often initially present
with more active and severe disease than adults, including a higher frequency of lupus …

Extracellular matrix (ECM) remodeling is strongly favored by the conditions occurring in the
inflammatory microenvironment and can lead to pathogenic reactions directed toward the …

Остеоартрит (ОА) является одной из актуальных проблем клинической медицины не
только вследствие большой распространенности, но и повышенной частоты …

The mammalian skeleton is largely composed of cartilage and bone. The major functions of
cartilage are first to provide a transient template for development of the axial and …

Aggrecan has been implied as an autoantigen in rheumatoid arthritis (RA). Immunization
with aggrecan induces arthritis in BALB/c (H‐2d) mice but not in other strains of mice [eg …

Osteoarthritis (OA) is among challenging problems of clinical medicine, not only due to its
high prevalence, but also because of higher burden of comorbidities. Previously we …