lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids,
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …

Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding
hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

Diversity and plasticity are two hallmarks of macrophages. M1 macrophages (classically
activated macrophages) are pro-inflammatory and have a central role in host defense …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Atherosclerosis is a progressive disease in which endothelial cell dysfunction, macrophage
foam cell formation, and smooth muscle cell migration and proliferation, lead to the loss of …

Atherosclerosis is an inflammatory disease of the wall of large-and medium-sized arteries
that is precipitated by elevated levels of low-density lipoprotein (LDL) cholesterol in the …

Vascular inflammation is associated with and in large part driven by changes in the
leukocyte compartment of the vessel wall. Here, we focus on monocyte influx during …

The oxidative modification hypothesis of atherosclerosis, which assigns to oxidized low‐
density lipoproteins (LDLs) a crucial role in atherosclerosis initiation and progression, is still …