Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer's disease
(AD) brain, and it does so with the full complexity of local peripheral inflammatory responses …

There is a great deal of evidence suggesting an important role for systemic inflammation in
the pathogenesis of A lzheimer's disease. The role of systemic inflammation, and indeed …

Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the
microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD …

Contrary to early views, we now know that systemic inflammatory/immune responses
transmit to the brain. The microglia, the resident “macrophages” of the brain's innate immune …

Generation of neurotoxic amyloid β peptides and their deposition along with neurofibrillary
tangle formation represent key pathological hallmarks in Alzheimer's disease (AD). Recent …

Generation and deposition of amyloid beta peptides and neurofibrillary tangle formation are
key mechanisms involved in AD pathogenesis. Recent evidence suggests that inflammatory …

J. Neurochem.(2010) 112, 1415–1430. Abstract Alzheimer's disease (AD) is an age‐related
neurodegenerative disease increasingly recognized as one of the most important medical …

There is compelling evidence that Alzheimer's disease (AD) amyloid-β (Aβ) deposition is
associated with a local inflammatory response, which is initiated by the activation of …

Neuroglial cells are fundamental for control of brain homeostasis and they represent the
intrinsic brain defence system. All forms in neuropathology therefore inevitably involve glia …

Objective: To determine the association between features of the insulin resistance syndrome
and Alzheimer's disease. Design: Cross sectional population based study. Subjects: 980 …