Trace amines and their receptors
Trace amines are endogenous compounds classically regarded as comprising β-
phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites …
phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites …
[HTML][HTML] Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges
The discovery in 2001 of a G protein-coupled receptor family, subsequently termed trace
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …
The compendium of self-enactable techniques to change and self-manage motivation and behaviour v. 1.0
Behaviour change techniques describe the content of behaviour change interventions, but
do not adequately account for the actions that people must themselves undertake to …
do not adequately account for the actions that people must themselves undertake to …
Significance of mammalian N, N-dimethyltryptamine (DMT): A 60-year-old debate
JH Jiménez, JC Bouso - Journal of Psychopharmacology, 2022 - journals.sagepub.com
N, N-dimethyltryptamine (DMT) is a potent psychedelic naturally produced by many plants
and animals, including humans. Whether or not DMT is significant to mammalian physiology …
and animals, including humans. Whether or not DMT is significant to mammalian physiology …
[HTML][HTML] TAAR1 dependent and independent actions of the potential antipsychotic and dual TAAR1/5-HT1A receptor agonist SEP-363856
Abstract SEP-363856 (SEP-856) is a novel antipsychotic under clinical development. It
displays a unique pattern of receptor interaction, with only weak (partial agonist) activity at …
displays a unique pattern of receptor interaction, with only weak (partial agonist) activity at …
[HTML][HTML] Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains
SM Underhill, PD Hullihen, J Chen… - Molecular …, 2021 - nature.com
The extensive use of amphetamines to treat attention deficit hyperactivity disorders in
children provides a compelling rationale for understanding the mechanisms of action of …
children provides a compelling rationale for understanding the mechanisms of action of …
[HTML][HTML] Gut bacteria and neuropsychiatric disorders
LMT Dicks, D Hurn, D Hermanus - Microorganisms, 2021 - mdpi.com
Bacteria in the gut microbiome plays an intrinsic part in immune activation, intestinal
permeability, enteric reflex, and entero-endocrine signaling. Apart from physiological and …
permeability, enteric reflex, and entero-endocrine signaling. Apart from physiological and …
[HTML][HTML] A perspective: active role of lipids in neurotransmitter dynamics
PA Postila, T Róg - Molecular Neurobiology, 2020 - Springer
Synaptic neurotransmission is generally considered as a function of membrane-embedded
receptors and ion channels in response to the neurotransmitter (NT) release and binding …
receptors and ion channels in response to the neurotransmitter (NT) release and binding …
[HTML][HTML] Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice
Stress management is necessary for vertebrate survival. Chronic stress drives depression by
excitation of the lateral habenula (LHb), which silences dopaminergic neurons in the ventral …
excitation of the lateral habenula (LHb), which silences dopaminergic neurons in the ventral …
[HTML][HTML] Fluorescent artificial receptor-based membrane assay (FARMA) for spatiotemporally resolved monitoring of biomembrane permeability
The spatiotemporally resolved monitoring of membrane translocation, eg, of drugs or toxins,
has been a long-standing goal. Herein, we introduce the fluorescent artificial receptor-based …
has been a long-standing goal. Herein, we introduce the fluorescent artificial receptor-based …