The transforming growth factor β (TGFβ) signaling family is evolutionarily conserved in
metazoans. The signal transduction mechanisms of TGFβ family members have been …

Nuclear pore complexes (NPCs) are channels for nucleocytoplasmic transport of proteins
and RNAs. However, it remains unclear whether composition, structure, and permeability of …

Germ layer formation is among the earliest differentiation events in metazoan embryos. In
triploblasts, three germ layers are formed, among which the endoderm gives rise to the …

A fundamental question in developmental biology is how the early embryo establishes the
spatial coordinate system that is later important for the organization of the embryonic body …

Maternal mRNAs and proteins dictate early embryonic development before zygotic genome
activation. In the absence of transcription, elaborate control of maternal mRNA translation is …

The maternal-to-zygotic transition is crucial in embryonic development, marked by the
degradation of maternally provided mRNAs and initiation of zygotic gene expression …

In vitro fertilized (IVF) embryos show both cell cycle and developmental arrest. We
previously showed oxidative damage activates the ATM→ Chk1→ Cdc25B/Cdc25C …

Background Nodal signalling is an absolute requirement for normal mesoderm and
endoderm formation in vertebrate embryos, yet the transcriptional networks acting directly …

Axis specification of the zebrafish embryo begins during oogenesis and relies on proper
formation of well-defined cytoplasmic domains within the oocyte. Upon fertilization …

In many animals, factors deposited by the mother into the egg control the earliest events in
development of the zygote. These maternal RNAs and proteins play critical roles in oocyte …