Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …

Publisher Summary This chapter briefly reviews the use of deuterium to alter the metabolic
properties of compounds and discusses the past and current development of potential …

A large number of enzymes need a metal ion to express their catalytic activity. Among the
different roles that metal ions can play in the catalytic event, the most common are their …

Neutron protein crystallography is a powerful tool for investigating protein chemistry
because it directly locates hydrogen atom positions in a protein structure. The visibility of …

Neutron scattering studies provide important information in structural biology that is not
accessible using other approaches. The uniqueness of the technique, and its …

Selective replacement of hydrogen atoms with deuterium (deuteration) has the unique
benefit of retaining the pharmacologic profile of physiologically active compounds while, in …

The scattering of neutrons can be used to provide information on the structure and dynamics
of biological systems on multiple length and time scales. Pursuant to a National Science …

HIV-1 Protease (HIV-1 PR) is one of the three enzymes essential for the replication process
of HIV-1 virus, which explains why it has been the main target for design of drugs against …

Metalloenzymes represent an important target space for drug discovery. A limitation to the
early development of metalloenzyme inhibitors has been the lack of established structure …