[HTML][HTML] Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives

CR Harrell, BS Markovic, C Fellabaum… - Biomedicine & …, 2019 - Elsevier
Osteoarthritis (OA) is a chronic, prevalent, debilitating joint disease characterized by
progressive cartilage degradation, subchondral bone remodeling, bone marrow lesions …

The therapeutic potential of mesenchymal stromal cells for regenerative medicine: current knowledge and future understandings

M Merimi, R El-Majzoub, L Lagneaux… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent decades, research on the therapeutic potential of progenitor cells has advanced
considerably. Among progenitor cells, mesenchymal stromal cells (MSCs) have attracted …

Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial

J Freitag, D Bates, J Wickham, K Shah… - Regenerative …, 2019 - Taylor & Francis
Aim: To evaluate the efficacy of autologous adipose-derived mesenchymal stem cell
(ADMSC) therapy on pain, function and disease modification in knee osteoarthritis. Methods …

MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment

WS Toh, RC Lai, JHP Hui, SK Lim - Seminars in cell & developmental …, 2017 - Elsevier
Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in
animal and clinical studies. The efficacy of MSC-based therapies which was previously …

Intra‐articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof‐of‐concept clinical trial

CH Jo, YG Lee, WH Shin, H Kim, JW Chai… - Stem …, 2014 - academic.oup.com
Mesenchymal stem cells (MSCs) are known to have a potential for articular cartilage
regeneration. However, most studies focused on focal cartilage defect through surgical …

[HTML][HTML] Mesenchymal stem cell related therapies for cartilage lesions and osteoarthritis

R Zhang, J Ma, J Han, W Zhang… - American journal of …, 2019 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a common degenerative joint disease characterized by cartilage
degradation, synovitis, subchondral bone sclerosis and osteophyte formation. Current …

Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy–a review

J Freitag, D Bates, R Boyd, K Shah, A Barnard… - BMC musculoskeletal …, 2016 - Springer
Osteoarthritis is a leading cause of pain and disability across the world. With an aging
population its prevalence is likely to further increase. Current accepted medical treatment …

Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study

L Orozco, A Munar, R Soler, M Alberca, F Soler… - …, 2013 - journals.lww.com
Background Osteoarthritis is the most prevalent joint disease and a frequent cause of joint
pain, functional loss, and disability. Osteoarthritis often becomes chronic, and conventional …

Mechanical stimulation of mesenchymal stem cells: Implications for cartilage tissue engineering

N Fahy, M Alini, MJ Stoddart - Journal of Orthopaedic Research …, 2018 - Wiley Online Library
Articular cartilage is a load‐bearing tissue playing a crucial mechanical role in diarthrodial
joints, facilitating joint articulation, and minimizing wear. The significance of biomechanical …

Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections

Y Song, H Du, C Dai, L Zhang, S Li… - Regenerative …, 2018 - Taylor & Francis
Aim: This study aimed to evaluate the safety and therapeutic potential of autologous human
adipose-derived mesenchymal stem cells (haMSCs) in patients with osteoarthritis. Materials …