Disentangling the complexity of nutrition, frailty and gut microbial pathways during aging: a focus on hippuric acid

A Ticinesi, A Guerra, A Nouvenne, T Meschi, S Maggi - Nutrients, 2023 - mdpi.com
Hippuric acid (HA) is a metabolite resulting from the hepatic glycine conjugation of benzoic
acid (BA) or from the gut bacterial metabolism of phenylalanine. BA is generally produced by …

Accounting gut microbiota as the mediator of beneficial effects of dietary (poly) phenols on skeletal muscle in aging

A Ticinesi, A Nouvenne, N Cerundolo, A Parise… - Nutrients, 2023 - mdpi.com
Sarcopenia, the age-related loss of muscle mass and function increasing the risk of disability
and adverse outcomes in older people, is substantially influenced by dietary habits. Several …

Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia

YX Xu, LD Liu, JY Zhu, SS Zhu, BQ Ye, JL Yang… - Cell Host & Microbe, 2024 - cell.com
Hyperuricemia induces inflammatory arthritis and accelerates the progression of renal and
cardiovascular diseases. Gut microbiota has been linked to the development of …

[HTML][HTML] lncRNA GPRC5D-AS1 as a ceRNA inhibits skeletal muscle aging by regulating miR-520d-5p

M Yu, X He, T Liu, J Li - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Sarcopenia induced by muscle aging is associated with negative outcomes in a variety of
diseases. Long non-coding RNAs are a class of RNAs longer than 200 nucleotides with …

Exploring Human Metabolome after Wine Intake—A Review

P Lekka, E Fragopoulou, A Terpou, M Dasenaki - Molecules, 2023 - mdpi.com
Wine has a rich history dating back to 2200 BC, originally recognized for its medicinal
properties. Today, with the aid of advanced technologies like metabolomics and …

Phytonutrients as potential dietary supplements to ameliorate sarcopenia via the involvement of autophagic pathway

Y Sun, Q Zheng, J Sun, L Wang, Y Li - Food Reviews International, 2024 - Taylor & Francis
Although sarcopenia has been a serious public health concern worldwide in recent years, its
effective prevention and intervention measures are still lacking. The latest research has …

[HTML][HTML] Fuzhuan brick tea extract ameliorates obesity-induced skeletal muscle atrophy by alleviating mitochondrial dysfunction in mice

A Yoo, J Ahn, HD Seo, JH Hahm, CH Jung… - The Journal of …, 2024 - Elsevier
Fuzhuan brick tea (FBT) is a post-fermented tea fermented by the fungus Eurotium cristatum
and is mainly produced in Hunan Province, China. Our previous study revealed that FBT …

Morpho-Functional Analyses Demonstrate That Tyrosol Rescues Dexamethasone-Induced Muscle Atrophy

S Salucci, S Burattini, I Versari… - Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Prolonged exposure to high dosages of dexamethasone, which is a synthetic glucocorticoid
and a well-known anti-inflammatory drug, may lead to an increase in reactive oxygen …

New Trends to Treat Muscular Atrophy: A Systematic Review of Epicatechin

IJS German, KT Pomini, JC Andreo, JVTC Shindo… - Nutrients, 2024 - mdpi.com
Epicatechin is a polyphenol compound that promotes skeletal muscle differentiation and
counteracts the pathways that participate in the degradation of proteins. Several studies …

[HTML][HTML] 3-(4-Hydroxy-3-methoxyphenyl) propionic acid mitigates dexamethasone-induced muscle atrophy by attenuating Atrogin-1 and MuRF-1 expression in mouse …

A Ulla, MM Rahman, T Uchida… - Journal of Clinical …, 2024 - pmc.ncbi.nlm.nih.gov
3-(4-Hydroxy-3-methoxyphenyl) propionic acid is an in vivo metabolite of 4-hydroxy-3-
methoxycinnamic acid which is abundantly found in coffee bean, rice bran, fruits, and …