Listen to an interview with Sean Morrison on the stem cells podcast Much has been made of
the idea that asymmetric cell division is a defining characteristic of stem cells that enables …

Tissue morphogenesis during development is dependent on activities of the cadherin family
of cell–cell adhesion proteins that includes classical cadherins, protocadherins, and atypical …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

Cortical development depends on the active integration of cell-autonomous and extrinsic
cues, but the coordination of these processes is poorly understood. Here, we show that the …

The skin constantly renews itself throughout adult life, and the hair follicle undergoes a
perpetual cycle of growth and degeneration. Stem cells (SCs) residing in the epidermis and …

The investigation into lineage allocation and early asymmetries in the pre-and peri-
implantation mouse embryo is gaining momentum. As we review here, new insights have …

Ten years ago, par-1 and par-3 were cloned as two of the six par genes essential for the
asymmetric division of the Caenorhabditis elegans zygote. PAR-1 is a protein kinase …

Neocortical precursor cells undergo symmetric and asymmetric divisions while producing
large numbers of diverse cortical cell types. In Drosophila, cleavage plane orientation …

The development of cancer is a multistep process in which the DNA of a single cell
accumulates mutations in genes that control essential cellular processes. Loss of cell–cell …

Correct establishment and maintenance of cell polarity is required for the development and
homeostasis of all metazoans. Cell-polarity mechanisms are responsible not only for the …