Adipogenesis: a complex interplay of multiple molecular determinants and pathways

MA Ambele, P Dhanraj, R Giles, MS Pepper - International journal of …, 2020 - mdpi.com
The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

Adipogenesis, osteogenesis, and chondrogenesis of human mesenchymal stem/stromal cells: a comparative transcriptome approach

AW Robert, BH Marcon, B Dallagiovanna… - Frontiers in cell and …, 2020 - frontiersin.org
Adipogenesis, osteogenesis and chondrogenesis of human mesenchymal stem/stromal
cells (MSC) are complex and highly regulated processes. Over the years, several studies …

Cells of the human intestinal tract mapped across space and time

R Elmentaite, N Kumasaka, K Roberts, A Fleming… - Nature, 2021 - nature.com
The cellular landscape of the human intestinal tract is dynamic throughout life, developing in
utero and changing in response to functional requirements and environmental exposures …

Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria

F Day, T Karaderi, MR Jones, C Meun, C He… - PLoS …, 2018 - journals.plos.org
Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism,
ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have …

Long non-coding RNAs in regulation of adipogenesis and adipose tissue function

T Squillaro, G Peluso, U Galderisi, G Di Bernardo - Elife, 2020 - elifesciences.org
Complex interaction between genetics, epigenetics, environment, and nutrition affect the
physiological activities of adipose tissues and their dysfunctions, which lead to several …

3D adipose tissue culture links the organotypic microenvironment to improved adipogenesis

JX Shen, M Couchet, J Dufau… - Advanced …, 2021 - Wiley Online Library
Obesity and type 2 diabetes are strongly associated with adipose tissue dysfunction and
impaired adipogenesis. Understanding the molecular underpinnings that control …

Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation

A Villatoro, V Cuminetti, A Bernal, C Torroja… - nature …, 2023 - nature.com
Here we explored the role of interleukin-1β (IL-1β) repressor cytokine, IL-1 receptor
antagonist (IL-1rn), in both healthy and abnormal hematopoiesis. Low IL-1RN is frequent in …

[HTML][HTML] Knock-down of circular RNA H19 induces human adipose-derived stem cells adipogenic differentiation via a mechanism involving the polypyrimidine tract …

Y Zhu, W Gui, X Lin, H Li - Experimental cell research, 2020 - Elsevier
Abstract Purpose The metabolic syndrome (MetS) is characterized of a cluster of medical
disorders. Altered function of adipose tissue has a significant impact on whole-body …

Identification of candidate genes regulating carcass depth and hind leg circumference in simmental beef cattle using Illumina Bovine Beadchip and next-generation …

F Bordbar, M Mohammadabadi, J Jensen, L Xu, J Li… - Animals, 2022 - mdpi.com
Simple Summary The performance of genome-wide association studies with high-density
single-nucleotide polymorphism panels and next-generation sequencing is a robust …

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

AE Justice, T Karaderi, HM Highland, KL Young… - Nature …, 2019 - nature.com
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We
analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for …