A new edition of the WHO classification of tumours of the CNS was published in 2021.
Although the previous edition of this classification was published just 5 years earlier, in …

The 2016 revised fourth edition of the World Health Organization (WHO) classification of
central nervous system (CNS) tumors incorporated molecular features with histologic …

Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …

Abstract cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to
CNS Tumor Taxonomy) was established to evaluate and make practical recommendations …

Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …

Advances in our understanding of the biological basis and molecular characteristics of
ependymal tumors since the latest iteration of the World Health Organization (WHO) …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Ependymoma is a heterogeneous entity of central nervous system tumors with well-
established molecular groups. Here, we apply single-cell RNA sequencing to analyze …

Of nine ependymoma molecular groups detected by DNA methylation profiling, the posterior
fossa type A (PFA) is most prevalent. We used DNA methylation profiling to look for further …

Summary H3K27M diffuse intrinsic pontine gliomas (DIPGs) are fatal and lack treatments.
They mainly harbor H3. 3K27M mutations resulting in H3K27me3 reduction. Integrated …