Dicoumarol, a symmetrical biscoumarin can be considered as the “parent” of the widely
used anticoagulant drug, warfarin. The discovery of dicoumarol's bioactive properties …

Disulfide bond formation is a catalyzed reaction essential for the folding and stability of
proteins in the secretory pathway. In prokaryotes, disulfide bonds are generated by DsbB or …

INTRODUCTION Vitamin K antagonists (VKAs), such as warfarin, are oral anticoagulants
commonly used to treat and prevent thromboembolic diseases, including stroke and heart …

Vitamin K: Past, Present, Future Essential for normal blood coagulation, possible roles in
bone, vascular, and tumor metabolism, and a nutrient critical to the health of the newborn …

The intramembrane vitamin K epoxide reductase (VKOR) supports blood coagulation in
humans and is the target of the anticoagulant warfarin. VKOR and its homologues generate …

Vitamin K epoxide reductase (VKOR) is essential for the production of reduced vitamin K that
is required for modification of vitamin K-dependent proteins. Three-and four-transmembrane …

The systematic use of antivitamin K anticoagulants (AVK) as rodenticides caused the
selection of rats resistant to AVKs. The resistance is mainly associated to genetic …

Vitamin K epoxide reductases (VKORs) are a large family of integral membrane enzymes
found from bacteria to humans. Human VKOR, specific target of warfarin, has both the …

Vitamin K antagonists (VKAs), such as warfarin, are oral anticoagulants widely used to treat
and prevent thromboembolic diseases. Therapeutic use of these drugs requires frequent …

Violaxanthin de-epoxidase (VDE) catalyses the conversion of violaxanthin to zeaxanthin at
the lumen side of the thylakoids during exposure to intense light. VDE consists of a cysteine …