Structural maintenance of chromosomes (SMC) complexes are key organizers of
chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such …

The chromosomal loci known as centromeres (CEN) mediate the equal distribution of the
duplicated genome between both daughter cells. Specifically, centromeres recruit a protein …

The Toll signaling pathway was initially identified for its involvement in the control of early
embryogenesis. It was later shown to be also part of a major innate immune pathway …

The ubiquitin E3 ligase Bre1-mediated H2B monoubiquitination (H2Bub) is essential for
proper DNA replication and repair in eukaryotes. Deficiency in H2Bub causes genome …

The centromere is a chromosomal region where the kinetochore is formed, which is the
attachment point of spindle fibers. Thus, it is responsible for the correct chromosome …

Accurate duplication of chromosomal DNA is vital for faithful transmission of the genome
during cell division. However, DNA replication integrity is frequently challenged by genotoxic …

Background The growing male reproductive diseases have been linked to higher exposure
to certain environmental compounds such as 2, 2′, 4, 4′-tetrabromodiphenyl ether …

Background The centromere is the specialized chromatin region that directs chromosome
segregation. The kinetochore assembles on the centromere, attaching chromosomes to …

Cip1, a newly identified yeast analog of p21, is a Cln3-CDK inhibitor that negatively
regulates cell-cycle START. However, its function remains poorly understood. In this study …

Cohesins promote proper chromosome segregation, gene transcription, genomic
architecture, DNA condensation, and DNA damage repair. Mutations in either cohesin …