Cholesterol is an essential component of cell membranes and the precursor for the
synthesis of steroid hormones and bile acids. The synthesis of this molecule occurs partially …

Significance: Cardiovascular diseases (CVD) represent a major public health burden. High
low-density lipoprotein (LDL)-cholesterol is a recognized pathogenic factor for …

This review provides an updated atomic-level perspective regarding the enzyme 3-hydroxy-
3-methylglutaryl coenzyme A reductase (HMG-CoAR), linking the more recent data on this …

Acute coronary syndrome (ACS) remains a major cause of morbidity and mortality
worldwide, requiring ongoing efforts to identify novel therapeutic targets to improve patient …

Centaurium erythraea is recommended for the treatment of gastrointestinal disorders and to
reduce hypercholesterolemia in ethno-medicinal practice. To perform a top-down study that …

HMG-CoA reductase (HMGR) is the target of statins, cholesterol-lowering drugs prescribed
to millions of patients worldwide. More recent research indicates that HMGR could be a …

The use of statins for cardiovascular disease (CVD) prevention is clearly supported by
clinical evidence. Although statin therapy is rather well tolerated, recent data from …

Statins represent the elective lipid-lowering strategy in hyperlipidemic and high
cardiovascular-risk patients. Despite excellent safety and tolerability, reversible muscle …

HMG-CoA reductase catalyzes the four-electron reduction of HMG-CoA to mevalonate and
is an enzyme of considerable biomedical relevance because of the impact of its statin …

In the search for new potential hypolipidemic agents, the present study focused on the
synthesis of 2-acyl phenols (6a–c and 7a–c) and their saturated side-chain alkyl phenols (4a …