Cerebral edema after ischemic stroke: Pathophysiology and underlying mechanisms

Y Gu, C Zhou, Z Piao, H Yuan, H Jiang, H Wei… - Frontiers in …, 2022 - frontiersin.org
Ischemic stroke is associated with increasing morbidity and has become the main cause of
death and disability worldwide. Cerebral edema is a serious complication arising from …

Research progress and challenges of stem cell therapy for ischemic stroke

Z Cha, Y Qiao, Q Lu, Q Wang, X Lu… - Frontiers in Cell and …, 2024 - frontiersin.org
Ischemic stroke is a significant global cause of death and disability. Currently, treatment
options for acute ischemic stroke are limited to intravenous thrombolysis and mechanical …

Selenium supplementation enhanced the expression of selenoproteins in hippocampus and played a neuroprotective role in LPS-induced neuroinflammation

X Liang, Z Xue, Y Zheng, S Li, L Zhou, L Cao… - International Journal of …, 2023 - Elsevier
Selenium (Se) is obtained from organic and inorganic selenium food content, which mainly
depends on the regional soil selenium content. Selenium deficiency and decreased …

Cardiolipin-mediated alleviation of mitochondrial dysfunction is a neuroprotective effect of statin in animal model of ischemic stroke

D Sarmah, A Sarkar, A Datta, B Ghosh… - ACS Chemical …, 2023 - ACS Publications
In clinical settings, the benefit of statin for stroke is debatable as regular statin users may
suffer from myalgia, statin-associated myopathy (SAM), and rarely rhabdomyolysis. Studies …

SIRT-1/RHOT-1/PGC-1α loop modulates mitochondrial biogenesis and transfer to offer resilience following endovascular stem cell therapy in ischemic stroke

D Sarmah, A Datta, N Rana, P Suthar, V Gupta… - Free Radical Biology …, 2024 - Elsevier
Current clinical interventions for stroke majorly involve thrombolysis or thrombectomy,
however, cessation of the progressive deleterious cellular cascades post-stroke and long …

[HTML][HTML] Inosine attenuates post-stroke neuroinflammation by modulating inflammasome mediated microglial activation and polarization

A Datta, P Suthar, D Sarmah, P Jadhav, J Shah… - … et Biophysica Acta (BBA …, 2023 - Elsevier
To date, various agents and molecules have been developed to treat post-stroke
neuroinflammation; however, none of them are clinically successful. Post-stroke …

Endovascular stem cell therapy promotes neuronal remodeling to enhance post stroke recovery by alleviating endoplasmic reticulum stress modulated by BDNF …

H Kaur, D Sarmah, A Datta, A Borah… - Stem Cell Reviews and …, 2023 - Springer
Abstract Background and Purpose The impact of increased BDNF expression in brain by
endovascular delivered mesenchymal stem cells (MSCs) post stroke towards modulating …

Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells

N Tan, W Xin, M Huang, Y Mao - Frontiers in Neurology, 2022 - frontiersin.org
Stroke, a cerebrovascular accident, is prevalent and the second highest cause of death
globally across patient populations; it is as a significant cause of morbidity and mortality …

The role of stem cells as therapeutics for ischaemic stroke

J Ya, J Pellumbaj, A Hashmat, U Bayraktutan - Cells, 2024 - mdpi.com
Stroke remains one of the leading causes of death and disability worldwide. Current
reperfusion treatments for ischaemic stroke are limited due to their narrow therapeutic …

Simvastatin exerts neuroprotective effects post-stroke by ameliorating endoplasmic reticulum stress and regulating autophagy/apoptosis balance through pAMPK …

B Ghosh, A Datta, V Gupta, B Sodnar, A Sarkar… - Experimental …, 2024 - Elsevier
Statins have evident neuroprotective role in acute ischemic stroke (AIS). The pleiotropic
effect by which statin exerts neuroprotective effects, needs to be explored for considering it …