Harnessing extracellular vesicle heterogeneity for diagnostic and therapeutic applications

RP Carney, RR Mizenko, BT Bozkurt, N Lowe… - Nature …, 2024 - nature.com
Extracellular vesicles (EVs) are diverse nanoparticles with large heterogeneity in size and
molecular composition. Although this heterogeneity provides high diagnostic value for liquid …

Mesenchymal stem cell-derived extracellular vesicles: opportunities and challenges for clinical translation

M Maumus, P Rozier, J Boulestreau… - … in Bioengineering and …, 2020 - frontiersin.org
Extracellular vesicles (EVs), including exosomes and microvesicles, derived from
mesenchymal stem/stromal cells (MSCs) exert similar effects as their parental cells, and are …

The cellular response to extracellular vesicles is dependent on their cell source and dose

DW Hagey, M Ojansivu, BR Bostancioglu, O Saher… - Science …, 2023 - science.org
Extracellular vesicles (EVs) have been established to play important roles in cell-cell
communication and shown promise as therapeutic agents. However, we still lack a basic …

Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells

A D'Souza, A Burch, KM Dave, A Sreeram… - Journal of Controlled …, 2021 - Elsevier
We have demonstrated, for the first time that microvesicles, a sub-type of extracellular
vesicles (EVs) derived from hCMEC/D3: a human brain endothelial cell (BEC) line transfer …

Final results of allogeneic adipose tissue–derived mesenchymal stem cells in acute ischemic stroke (AMASCIS): A phase II, randomized, double-blind, placebo …

E de Celis-Ruiz, B Fuentes… - Cell …, 2022 - journals.sagepub.com
Acute ischemic stroke is currently a major cause of disability despite improvement in
recanalization therapies. Stem cells represent a promising innovative strategy focused on …

Comprehensive bibliometric analysis of stem cell research in Alzheimer's disease from 2004 to 2022

R Wang, Y Zhu, LF Qin, ZG Xu, XR Gao… - Dementia and Geriatric …, 2023 - karger.com
Introduction: Stem cell-based regenerative medicine has provided an excellent opportunity
to investigate therapeutic strategies and innovative treatments for Alzheimer's disease (AD) …

Mesenchymal stem cell therapy for ischemic stroke: a look into treatment mechanism and therapeutic potential

J Li, Q Zhang, W Wang, F Lin, S Wang, J Zhao - Journal of neurology, 2021 - Springer
Stroke, a global disease with a high disability rate, has limited options for functional
rehabilitation and results in an adverse impact on patients' lives. In recent years …

Native and bioengineered exosomes for ischemic stroke therapy

H Khan, JJ Pan, Y Li, Z Zhang, GY Yang - Frontiers in Cell and …, 2021 - frontiersin.org
Exosomes are natural cells-derived vesicles, which are at the forefront toward clinical
success for various diseases, including cerebral ischemia. Exosomes mediate cell-to-cell …

Promising opportunities for treating neurodegenerative diseases with mesenchymal stem cell-derived exosomes

R Guy, D Offen - Biomolecules, 2020 - mdpi.com
Neurodegenerative disease refers to any pathological condition in which there is a
progressive decline in neuronal function resulting from brain atrophy. Despite the immense …

Role of extracellular vesicles in neurodegenerative diseases

Y Xiao, SK Wang, Y Zhang, A Rostami, A Kenkare… - Progress in …, 2021 - Elsevier
Extracellular vesicles (EVs) are heterogeneous cell-derived membranous structures that
arise from the endosome system or directly detach from the plasma membrane. In recent …