DNA hypermethylation in disease: mechanisms and clinical relevance

M Ehrlich - Epigenetics, 2019 - Taylor & Francis
Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

[HTML][HTML] Advances and challenges in thyroid cancer: The interplay of genetic modulators, targeted therapies, and AI-driven approaches

S Bhattacharya, RK Mahato, S Singh, GK Bhatti… - Life Sciences, 2023 - Elsevier
Thyroid cancer continues to exhibit a rising incidence globally, predominantly affecting
women. Despite stable mortality rates, the unique characteristics of thyroid carcinoma …

The relationship between thyrotropin serum concentrations and thyroid carcinoma

X Zhang, L Tian, D Teng, W Teng - Cancers, 2023 - mdpi.com
Simple Summary Thyroid-stimulating hormone (TSH) plays a role in the regulation of thyroid
hormones and is an important indicator for assessing thyroid function. Thyroid cancer (TC) is …

Epigenetic modification and BRAF gene mutation in thyroid carcinoma

G Huang, J Chen, J Zhou, S Xiao, W Zeng, J Xia… - Cancer cell …, 2021 - Springer
Thyroid cancer remains the most prevailing endocrine malignancy, and a progressively
increasing incidence rate has been observed in recent years, with 95% of thyroid cancer …

The molecular function and clinical role of thyroid stimulating hormone receptor in cancer cells

YD Chu, CT Yeh - Cells, 2020 - mdpi.com
The thyroid stimulating hormone (TSH) and its cognate receptor (TSHR) are of crucial
importance for thyrocytes to proliferate and exert their functions. Although TSHR is …

Mechanisms of senescence in cancer: positive and negative aspects of cancer cells senescence

A Zaczek, S Kalenik, A Rodacka - Cellular Physiology and …, 2023 - publicum.umed.lodz.pl
Cell senescence was considered an attribute of normal dividing cells, which distinguishing
them from cancer cells that do not have a division limit. However, recent studies show that …

[HTML][HTML] VASN promotes YAP/TAZ and EMT pathway in thyroid carcinogenesis in vitro

A Bhandari, Y Guan, E Xia, Q Huang… - American Journal of …, 2019 - ncbi.nlm.nih.gov
Background: Thyroid cancer incidence has been continuity growing globally. To Find
reliable molecular biomarkers to assess prognosis and select optimal treatment is …

Targeting Thyroid-Stimulating Hormone Receptor: A Perspective on Small-Molecule Modulators and Their Therapeutic Potential

Y Zhang, Y Tan, Z Zhang, X Cheng… - Journal of Medicinal …, 2024 - ACS Publications
TSHR is a member of the glycoprotein hormone receptors, a subfamily of class A G-protein-
coupled receptors and plays pivotal roles in various physiological and pathological …

Whether Detection of Gene Mutations Could Identify Low‐or High‐Risk Papillary Thyroid Microcarcinoma? Data from 393 Cases Using the Next‐Generation …

L Jin, L Zhou, JB Wang, L Tao, XX Lu… - International Journal …, 2024 - Wiley Online Library
Objective. The objective of this study is to explore the utilization of next‐generation
sequencing (NGS) technology in evaluating the likelihood of identifying individuals with …

Development and validation of potential molecular subtypes and signatures of thyroid carcinoma based on aging-related gene analysis

Z Li, LI Jia, HR Zhou, LU Zhang, M Zhang… - Cancer Genomics & …, 2024 - cgp.iiarjournals.org
Abstract Background/Aim: Thyroid carcinoma (THCA) is a cancer of the endocrine system
that most commonly affects women. Aging-associated genes play a critical role in various …