Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

Background—Hypoxia induces an inflammatory response in the lung manifested by
alternative activation of macrophages with elevation of proinflammatory mediators that are …

Since its discovery two decades ago, the activation of the Janus kinase/signal transducers
and activators of transcription (JAK/STAT) pathway by numerous cytokines and growth …

Background The hyper-IgE syndrome (or Job's syndrome) is a rare disorder of immunity and
connective tissue characterized by dermatitis, boils, cyst-forming pneumonias, elevated …

Alveolar epithelial regeneration is essential for recovery from devastating lung diseases.
This process occurs when type II alveolar pneumocytes (AT2 cells) proliferate and …

The pseudostratified airway epithelium of the lung contains a balanced proportion of
multiciliated and secretory luminal cells that are maintained and regenerated by a …

In clinical settings, oxygen therapy is administered to preterm neonates and to adults with
acute and chronic conditions such as COVID-19, pulmonary fibrosis, sepsis, cardiac arrest …

Members of the signal transducers and activators of transcription (STAT) pathway, which
were originally identified as key components linking cytokine signals to transcriptional …

The vertebrate lung consists of multiple cell types that are derived primarily from endodermal
and mesodermal compartments of the early embryo. The process of pulmonary …