Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

Nanozymes, nanomaterials exhibiting enzyme-like activities, have emerged as a prominent
interdisciplinary field over the past decade. To date, over 1200 different nanomaterials have …

RelA/SpoT Homologue (RSH) proteins, named for their sequence similarity to the RelA and
SpoT enzymes of Escherichia coli, comprise a superfamily of enzymes that synthesize …

Enzymatic proteolysis of cell surface proteins and extracellular matrix (ECM) is critical for
tissue homeostasis and cell signaling. These proteolytic activities are mediated …

With the increased focus on intrinsically disordered proteins (IDPs) and their large
interactomes, the question about their specificity—or more so on their multispecificity—arise …

GRN mutations cause frontotemporal lobar degeneration with TDP-43-positive inclusions.
The mechanism of pathogenesis is haploinsufficiency. Recently, homozygous GRN …

Antibodies are essential components of adaptive immunity. A typical antibody repertoire
comprises an enormous diversity of antigen-binding specificities, which are generated by …

Site-specific proteolysis by the enzymatic cleavage of small linear sequence motifs is a key
posttranslational modification involved in physiology and disease. The ability to robustly and …

Viral proteins bind to numerous cellular and viral proteins throughout the infection cycle.
However, the mechanisms by which viral proteins interact with such large numbers of factors …

MMP‐14 and MMP‐9 are two well‐established cancer targets for which no specific clinically
relevant inhibitor is available. Using a powerful combination of computational design and …