Epigenetic mechanisms of longevity and aging

P Sen, PP Shah, R Nativio, SL Berger - Cell, 2016 - cell.com
Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

Biomarkers of cellular senescence and skin aging

AS Wang, O Dreesen - Frontiers in genetics, 2018 - frontiersin.org
Cellular senescence is an irreversible growth arrest that occurs as a result of different
damaging stimuli, including DNA damage, telomere shortening and dysfunction or …

[HTML][HTML] Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

S Horvath, J Oshima, GM Martin, AT Lu… - Aging (Albany …, 2018 - ncbi.nlm.nih.gov
DNA methylation (DNAm)-based biomarkers of aging have been developed for many
tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts …

LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes

F Della Valle, P Reddy, M Yamamoto, P Liu… - Science Translational …, 2022 - science.org
Constitutive heterochromatin is responsible for genome repression of DNA enriched in
repetitive sequences, telomeres, and centromeres. During physiological and pathological …

Molecular pathology of laminopathies

JY Shin, HJ Worman - Annual Review of Pathology …, 2022 - annualreviews.org
The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

[HTML][HTML] Remodeling of bone marrow hematopoietic stem cell niches promotes myeloid cell expansion during premature or physiological aging

YH Ho, R Del Toro, J Rivera-Torres, J Rak, C Korn… - Cell stem cell, 2019 - cell.com
Hematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during
aging but are functionally impaired. However, the role of HSC-intrinsic and-extrinsic aging …

Nuclear DNA damage signalling to mitochondria in ageing

EF Fang, M Scheibye-Knudsen, KF Chua… - … reviews Molecular cell …, 2016 - nature.com
Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead
to increased healthspan. Emerging evidence suggests a crucial role for signalling from the …

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

N Kubben, T Misteli - Nature Reviews Molecular Cell Biology, 2017 - nature.com
Ageing is the predominant risk factor for many common diseases. Human premature ageing
diseases are powerful model systems to identify and characterize cellular mechanisms that …

[HTML][HTML] SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity

G Lee, YY Kim, H Jang, JS Han, H Nahmgoong… - Cell metabolism, 2022 - cell.com
Emerging evidence indicates that the accretion of senescent cells is linked to metabolic
disorders. However, the underlying mechanisms and metabolic consequences of cellular …

[HTML][HTML] The role of cellular senescence in skin aging and age-related skin pathologies

T Chin, Y Lee, O Dreesen - Frontiers in physiology, 2023 - frontiersin.org
Aging is the result of a gradual functional decline at the cellular, and ultimately, organismal
level, resulting in an increased risk of developing a variety of chronic illnesses, such as …