Mitochondria are critically involved in reactive oxygen species (ROS)-dependent lung
diseases, such as lung fibrosis, asbestos, chronic airway diseases and lung cancer …

Convincing evidence has emerged demonstrating that impairment of mitochondrial function
is critically important in regulating alveolar epithelial cell (AEC) programmed cell death …

Mitochondria-targeted human 8-oxoguanine DNA glycosylase (mt-hOgg1) and aconitase-2
(Aco-2) each reduce oxidant-induced alveolar epithelial cell (AEC) apoptosis, but it is …

Aging is characterized by a progressive decline in organism functions due to the impairment
of all organs. The deterioration of both proliferative tissues in liver, skin and the vascular …

Biological effects of high fluence low-power (HFLP) lasers have been reported for some
time, yet the molecular mechanisms procuring cellular responses remain obscure. A better …

Asbestos causes asbestosis and malignancies by mechanisms that are not fully established.
Alveolar epithelial cell (AEC) injury and repair are crucial determinants of the fibrogenic …

The coordination of nuclear and mitochondrial genomes plays a pivotal role in maintenance
of mitochondrial biogenesis and functionality during stress and aging. Environmental and …

CD147 is a membrane protein belonging to immunoglobulin superfamily and expressed in
the cell membrane, which is also named with an extracellular matrix metalloproteinase …

Abstract The Guardian of the Genome p53 has been established as a potent tumour
suppressor. However, culminating from seminal findings in rodents more than a decade ago …

Asbestos mineral-fibre exposure is a well established cause of pulmonary fibrosis
(asbestosis) and malignancies (bronchogenic carcinoma and mesothelioma). In this …