Cancers have the ability to develop resistance to traditional therapies, and the increasing
prevalence of these drug resistant cancers necessitates further research and treatment …

Drug resistance is of great concern in cancer treatment because most effective drugs are
limited by the development of resistance following some periods of therapeutic …

Imatinib resistance remains an unresolved problem in CML disease. Activation of
JAK2/STAT3 pathway and increased expression of RUNX1 have become one reason for …

The onset of global epigenetic changes in chromatin that drive tumor proliferation and
heterogeneity is a hallmark of many forms of cancer. Identifying the epigenetic mechanisms …

Simple Summary The suppressors of cytokine signaling (SOCS) are known cytokine-
inducible negative regulators of JAK/STAT and other cell signaling pathways. Deregulation …

Background Tumor-suppressor genes are inactivated by methylation in several cancers
including acute myeloid leukemia (AML). Src homology-2 (SH2)-containing protein-tyrosine …

Cancer is a complex disease that has the ability to develop resistance to traditional
therapies. The current chemotherapeutic treatment has become increasingly sophisticated …

Background Abnormal expression of SOCS3 has been implicated in myeloproliferative
neoplasms, but the role of SOCS3 in the pathogenesis of leukemia remains largely …

Background: The present study aims to investigate the protective effects of the SOCS1-JAK2-
STAT3 signaling pathway on neurons in a rat model of ischemic stroke. Methods: Our study …

Neuropathic pain is an incapacitating disease that affects a large number of people
worldwide, but effective therapies have not yet been established. microRNAs (miRs) are …