Highlights•Metabolomics has become a widely applied tool in drug development.•
Metabolomics plays a key role for the identification of physiological response markers.• …

Fungi and antifungal compounds are relevant to the United Nation's Sustainable
Development Goals. However, the modes‐of‐action of antifungals—whether they are …

Genetic, epidemiologic, and biochemical evidence suggests that predisposition to
Alzheimer's disease (AD) may arise from altered cholesterol metabolism, although the …

Fungal infections cause more than 1.5 million deaths annually. With an increase in immune-
deficient susceptible populations and the emergence of antifungal drug resistance, there is …

Azole antifungals inhibit the sterol C14-demethylase (CYP51/Erg11) of the ergosterol
biosynthesis pathway. Here we show that the azole-induced synthesis of fungicidal cell wall …

Despite being a relatively new addition to the Omics' landscape, lipidomics is increasingly
being recognized as an important tool for the identification of druggable targets and …

Azole antifungals remain the “gold standard” therapy for invasive aspergillosis. The world-
wide emergence of isolates resistant to this drug class, however, developed into a steadily …

Distal cholesterol biosynthesis (CB) has recently taken center stage as a promising drug
target in several diseases previously not linked to this biochemical pathway, including …

Treatment of life-threatening cryptococcal meningitis (CM) is highly challenging due to the
limited efficacy of the available antifungal drugs. Antidepressant sertraline (SER) has been …

Multi-resistant microorganisms continue to challenge medicine and fuel the search for new
antimicrobials. Here we show that essential oils and their components are a promising class …