Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Understanding the interface between nanomaterials and lipoproteins is crucial for gaining
insights into their impact on lipoprotein structure and lipid metabolism. Here, we use …

A lipid nanodisc is a discoidal lipid bilayer stabilized by proteins, peptides, or polymers on its
edge. Nanodiscs have two important connections to structural biology. The first is associated …

Intracellular lipid droplets (LDs) are the main cellular site of metabolic energy storage. Their
structure is unique inside the cell, with a core of esterified fatty acids and sterols, mainly …

Surface lipids influence the biological activities of high-density lipoproteins (HDLs) but their
species-specific effects on HDL structure, dynamics, and surface interactome has remained …

Lipid droplets (LDs) are energy storage organelles composed of neutral lipids, such as
triacylglycerol (TG) and sterol esters, surrounded by a phospholipid (PL) monolayer. Their …

High-density lipoproteins (HDLs) are known to enhance vascular function through different
mechanisms, including the delivery of functional lipids to endothelial cells. Therefore, we …

Human serum high-density lipoproteins (HDLs) are a population of small, dense protein-
lipid aggregates that are crucial for intravascular lipid trafficking and are protective against …

Plasma lipoproteins are macromolecular assemblies of proteins and lipids found in the
blood. The lipid components of lipoproteins are amphipathic lipids such as phospholipids …

The mechanistic details behind the activation of lecithin–cholesterol acyltransferase (LCAT)
by apolipoprotein AI (apoA-I) and its mimetic peptides are still enigmatic. Resolving the …