Natural products as multidrug resistance modulators in cancer

A Kumar, V Jaitak - European journal of medicinal chemistry, 2019 - Elsevier
Cancer is a prominent cause of death globally. Currently, many drugs that are in clinical
practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors …

Kaempferol, a potential cytostatic and cure for inflammatory disorders

P Rajendran, T Rengarajan, N Nandakumar… - European journal of …, 2014 - Elsevier
Abstract Kaempferol (3, 5, 7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a
flavonoid found in many edible plants (eg, tea, broccoli, cabbage, kale, beans, endive, leek …

Role of the blood–brain barrier in the nutrition of the central nervous system

P Campos-Bedolla, FR Walter, S Veszelka… - Archives of medical …, 2014 - Elsevier
The blood–brain barrier (BBB) is a dynamic and complex interface between the blood and
the central nervous system regulating brain homeostasis. Major functions of the BBB include …

[HTML][HTML] Kaempferol-loaded mucoadhesive nanoemulsion for intranasal administration reduces glioma growth in vitro

M Colombo, F Figueiró, A de Fraga Dias… - International journal of …, 2018 - Elsevier
In order to search for new approaches to treat glioma, intranasal administration has been
proposed as an alternative route to deliver drugs into the brain. Among the drug alternatives …

Carica papaya: comprehensive overview of the nutritional values, phytochemicals and pharmacological activities

OR Alara, NH Abdurahman, JA Alara - Advances in traditional medicine, 2020 - Springer
Carica papaya is a perennial large herbaceous plant known for diverse biological activities.
Different parts of this plant such as seeds, leaves, fruits, peels, roots, and stems have been …

Polyphenols beyond barriers: a glimpse into the brain

I Figueira, R Menezes, D Macedo… - Current …, 2017 - ingentaconnect.com
Background: Ageing can be simply defined as the process of becoming older, which is
genetically determined but also environmentally modulated. With the continuous increase of …

Anticancer activity of Carica papaya: A review

TTT Nguyen, PN Shaw, MO Parat… - Molecular nutrition & …, 2013 - Wiley Online Library
C arica papaya is widely cultivated in tropical and subtropical countries and is used as food
as well as traditional medicine to treat a range of diseases. Increasing anecdotal reports of …

Role of flavonoids against adriamycin toxicity

MD Navarro-Hortal, A Varela-López… - Food and Chemical …, 2020 - Elsevier
Abstract Doxorubicin (DOX), or adriamycin, is an anthracycline antineoplastic drug widely
used in the chemotherapy of a large variety of cancers due to its potency and action …

The role of dietary flavonoids for modulation of ATP binding cassette transporter mediated multidrug resistance

H Teng, H Deng, Y He, Q Lv, L Chen - eFood, 2021 - Wiley Online Library
Flavonoids are widely existing compounds with enormous pharmacological effects from food
and medicine. However, the low bioavailability in intestinal absorption and metabolism limits …

[PDF][PDF] Kaempferol exerts anti-proliferative effects on human ovarian cancer cells by inducing apoptosis, G0/G1 cell cycle arrest and modulation of MEK/ERK and …

S Yang, L Si, Y Jia, W Jian, Q Yu, M Wang, R Lin - J buon, 2019 - jbuon.com
Purpose: Ovarian cancer causes significant mortality in women and is one of the most
prevalent types of gynaecological cancer world over. Ovarian cancer is often diagnosed at …