Advances in ex vivo expansion of hematopoietic stem and progenitor cells for clinical applications

A Branco, J Rayabaram, CC Miranda… - … in Bioengineering and …, 2024 - frontiersin.org
As caretakers of the hematopoietic system, hematopoietic stem cells assure a lifelong supply
of differentiated populations that are responsible for critical bodily functions, including …

Distinct profile of CD34+ cells and plasma-derived extracellular vesicles from triple-negative patients with Myelofibrosis reveals potential markers of aggressive …

D Forte, M Barone, C Morsiani, G Simonetti… - Journal of Experimental …, 2021 - Springer
Background Myelofibrosis (MF) is a clonal disorder of hemopoietic stem/progenitor cells
(HSPCs) with high prevalence in elderly patients and mutations in three driver genes (JAK2 …

A novel branched DNA-based flowcytometric method for single-cell characterization of gene therapy products and expression of therapeutic genes

L Garcia-Perez, MCJA Van Eggermond… - Frontiers in …, 2021 - frontiersin.org
Many preclinical and clinical studies of hematopoietic stem cell-based gene therapy (GT)
are based on the use of lentiviruses as the vector of choice. Assessment of the vector titer …

Manufacturing of human T-lymphoid progenitors from two different hematopoietic stem cell sources and perspective for new immunotherapies

P Gaudeaux, RD Moirangthem, P Rault… - Journal of Cellular …, 2022 - scientificarchives.com
The adaptive immune system depends on the efficient response of lymphocytes, protecting
the organism from infection or malignant diseases. T-cell immunodeficiency, innate or …

[PDF][PDF] A Novel Branched DNA-Based Flowcytometric Method for Single-Cell Characterization of Gene Therapy Products and Expression of Therapeutic Genes

MLP van der Hoorn, K Pike-Overzet, FJT Staal - scholarlypublications …
Many preclinical and clinical studies of hematopoietic stem cell-based gene therapy (GT)
are based on the use of lentiviruses as the vector of choice. Assessment of the vector titer …

Immunological Difference between Cord and Peripheral Blood

HYM Sadek, MS Al-Haggar, AD Mohamad… - The Egyptian Journal of … - journals.ekb.eg
Most people feel that transplanting Cord Blood (CB) is a promising substitute for bone
marrow transplants. There are several causes for this, the two most contentious of which are …

[PDF][PDF] A Novel branched DNA-based flowcytometric method for single-cell characterization of gene therapy products and expression of therapeutic genes

LG Perez, MCJA van Eggermond, E Maietta… - scholarlypublications …
Many preclinical and clinical studies of hematopoietic stem cell0based gene therapy (GT)
are based on the use of lentiviruses as the vector of choice. Assessment of the vector titer …

1Oral Biology Department, Faculty of Dentistry, University of Strasbourg, Strasbourg, France, 2INSERM UMR_S 1109 (Molecular ImmunoRheumatology unit) …

S Jung, F Meyer - … for Organ and Tissue Regeneration: New …, 2020 - books.google.com
The use of any biomaterial will trigger the immune response regardless of its composition
(synthetic or natural). Indeed, it results in the break of the body's physical and chemical …

Immune cells: sources, properties, and cell types

S Jung, F Meyer - Biomaterials for Organ and Tissue Regeneration, 2020 - Elsevier
The use of any biomaterials implies to trigger immune response no matter the composition
(synthetic or natural). Indeed, it results in breakage of the physical and chemical barriers of …