Experimental approaches to tracking mobile genetic elements in microbial communities

CC Saak, CB Dinh, RJ Dutton - FEMS Microbiology Reviews, 2020 - academic.oup.com
Horizontal gene transfer is an important mechanism of microbial evolution and is often
driven by the movement of mobile genetic elements between cells. Due to the fact that …

Insights and genetic features of extended-spectrum beta-lactamase producing Escherichia coli isolates from two hospitals in Ghana

S Mahazu, W Sato, A Ayibieke, I Prah, T Hayashi… - Scientific Reports, 2022 - nature.com
Recently, the emergence and rapid dissemination of extended-spectrum beta-lactamase
(ESBL)-producing bacteria, particularly of the family Enterobacteriaceae, has posed serious …

KPC-2-producing Klebsiella pneumoniae ST147 in a neonatal unit: clonal isolates with differences in colistin susceptibility attributed to AcrAB-TolC pump

S Naha, K Sands, S Mukherjee, C Roy… - International journal of …, 2020 - Elsevier
This study characterizes four KPC-2-producing Klebsiella pneumoniae isolates from
neonates belonging to a single sequence type 147 (ST147) in relation to carbapenem …

Human milk microbiota: transferring the antibiotic resistome to infants

L Das, R Virmani, V Sharma, D Rawat… - Indian journal of …, 2019 - Springer
Commensal bacterial population is believed to be a reservoir for antibiotic resistance genes
(ARGs). The infant gut microbiota has relatively higher abundance of ARGs than the adults …

Epidemic HI2 Plasmids Mobilising the Carbapenemase Gene blaIMP-4 in Australian Clinical Samples Identified in Multiple Sublineages of Escherichia coli ST216 …

H Tarabai, ER Wyrsch, I Bitar, M Dolejska… - Microorganisms, 2021 - mdpi.com
Escherichia coli ST216, including those that carry bla KPC-2, bla FOX-5, bla CTX-M-15 and
mcr-1, have been linked to wild and urban-adapted birds and the colonisation of hospital …

Experimental support for multidrug resistance transfer potential in the preterm infant gut microbiota

M Hagbø, A Ravi, IL Angell, M Sunde, J Ludvigsen… - Pediatric …, 2020 - nature.com
Background There is currently a lack of experimental evidence for horizontal gene transfer
(HGT) mechanisms in the human gut microbiota. The aim of this study was therefore to …

Comparative genomic analysis of plasmids harboring bla OXA-48-like genes in Klebsiella pneumoniae

W Li, H Guo, Y Gao, X Yang, R Li, S Li… - Frontiers in Cellular …, 2022 - frontiersin.org
The emergence and spread of carbapenem-resistant Klebsiella pneumoniae (CRKP) is a
serious medical problem worldwide. Acquired OXA-48-like carbapenemases encoded by …

In silico characterization of IncX3 plasmids carrying bla OXA-181 in Enterobacterales

Z Yu, Z Zhang, L Shi, S Hua, T Luan, Q Lin… - Frontiers in Cellular …, 2022 - frontiersin.org
Carbapenem-resistant Enterobacterales poses a global urgent antibiotic resistance threat
because of its ability to transfer carbapenemase genes to other bacteria via horizontal gene …

Transmission Dynamics of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 Strains Carrying Capsular Loci KL64 and rmpA/rmpA2 Genes

Y Kong, Q Sun, H Chen, MS Draz, X Xie… - Frontiers in …, 2021 - frontiersin.org
The presence and dissemination of carbapenem-resistant Klebsiella pneumoniae (CRKP)
often cause life-threatening infections worldwide, but the therapeutic option is limited. In this …

Genetic Diversity and Characteristics of blaNDM-Positive Plasmids in Escherichia coli

Z Zhang, H Guo, X Li, W Li, G Yang, W Ni… - Frontiers in …, 2021 - frontiersin.org
New Delhi metallo-β-lactamases (NDMs), including at least 28 variants, are a rapidly
emerging family of β-lactamases worldwide, with a variety of infections caused by NDM …