[HTML][HTML] Overview of myelin, major myelin lipids, and myelin-associated proteins

A Kister, I Kister - Frontiers in Chemistry, 2023 - frontiersin.org
Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains
the main characteristics of biological membranes, such as lipid bilayer, but differs from them …

Promise and pitfalls of g-ratio estimation with MRI

JSW Campbell, IR Leppert, S Narayanan, M Boudreau… - Neuroimage, 2018 - Elsevier
The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a
myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for …

The role of myelination in measures of white matter integrity: combination of diffusion tensor imaging and two-photon microscopy of CLARITY intact brains

EH Chang, M Argyelan, M Aggarwal, TSS Chandon… - Neuroimage, 2017 - Elsevier
Diffusion tensor imaging (DTI) is used extensively in neuroscience to noninvasively estimate
white matter (WM) microarchitecture. However, the diffusion signal is inherently ambiguous …

Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain

DF Niño, Q Zhou, Y Yamaguchi, LY Martin… - Science translational …, 2018 - science.org
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant.
One of the most important long-term complications observed in children who survive NEC …

Along-axon diameter variation and axonal orientation dispersion revealed with 3D electron microscopy: implications for quantifying brain white matter microstructure …

HH Lee, K Yaros, J Veraart, JL Pathan… - Brain Structure and …, 2019 - Springer
Tissue microstructure modeling of diffusion MRI signal is an active research area striving to
bridge the gap between macroscopic MRI resolution and cellular-level tissue architecture …

[HTML][HTML] Whole-Brain In-vivo Measurements of the Axonal G-Ratio in a Group of 37 Healthy Volunteers

S Mohammadi, D Carey, F Dick, J Diedrichsen… - Frontiers in …, 2015 - frontiersin.org
The g-ratio, quantifying the ratio between the inner and outer diameters of a fiber, is an
important microstructural characteristic of fiber pathways and is functionally related to …

Evaluating g-ratio weighted changes in the corpus callosum as a function of age and sex

S Berman, KL West, MD Does, JD Yeatman, AA Mezer - Neuroimage, 2018 - Elsevier
Recent years have seen a growing interest in relating MRI measurements to the structural-
biophysical properties of white matter fibers. The fiber g-ratio, defined as the ratio between …

[HTML][HTML] The impact of realistic axonal shape on axon diameter estimation using diffusion MRI

HH Lee, SN Jespersen, E Fieremans, DS Novikov - Neuroimage, 2020 - Elsevier
To study axonal microstructure with diffusion MRI, axons are typically modeled as straight
impermeable cylinders, whereby the transverse diffusion MRI signal can be made sensitive …

[HTML][HTML] Mapping an index of the myelin g-ratio in infants using magnetic resonance imaging

DC Dean III, J O'Muircheartaigh, H Dirks, BG Travers… - Neuroimage, 2016 - Elsevier
Optimal myelination of neuronal axons is essential for effective brain and cognitive function.
The ratio of the axon diameter to the outer fiber diameter, known as the g-ratio, is a reliable …

Myelin volume fraction imaging with MRI

KL West, ND Kelm, RP Carson, DF Gochberg, KC Ess… - Neuroimage, 2018 - Elsevier
MRI is a valuable tool to assess myelin during development and demyelinating disease
processes. While multiexponential T 2 and quantitative magnetization transfer measures …