The crown and the scepter: roles of the protein corona in nanomedicine

R Cai, C Chen - Advanced Materials, 2019 - Wiley Online Library
Engineering nanomaterials are increasingly considered promising and powerful biomedical
tools or devices for imaging, drug delivery, and cancer therapies, but few nanomaterials …

Protein corona: a new approach for nanomedicine design

VH Nguyen, BJ Lee - International journal of nanomedicine, 2017 - Taylor & Francis
After administration of nanoparticle (NP) into biological fluids, an NP–protein complex is
formed, which represents the “true identity” of NP in our body. Hence, protein–NP interaction …

Nanoparticle–cell interactions: molecular structure of the protein corona and cellular outcomes

CC Fleischer, CK Payne - Accounts of chemical research, 2014 - ACS Publications
Conspectus The use of nanoparticles (NPs) in biology and medicine requires a molecular-
level understanding of how NPs interact with cells in a physiological environment. A critical …

Catalytic properties and biomedical applications of cerium oxide nanoparticles

C Walkey, S Das, S Seal, J Erlichman… - Environmental …, 2015 - pubs.rsc.org
Cerium oxide nanoparticles (nanoceria) have shown promise as catalytic antioxidants in the
test tube, cell culture models and animal models of disease. However given the reactivity …

Barriers to drug delivery in solid tumors

SK Sriraman, B Aryasomayajula, VP Torchilin - Tissue barriers, 2014 - Taylor & Francis
Over the last decade, significant progress has been made in the field of drug delivery. The
advent of engineered nanoparticles has allowed us to circumvent the initial limitations to …

Fabrication of corona-free nanoparticles with tunable hydrophobicity

DF Moyano, K Saha, G Prakash, B Yan, H Kong… - ACS …, 2014 - ACS Publications
A protein corona is formed at the surface of nanoparticles in the presence of biological fluids,
masking the surface properties of the particle and complicating the relationship between …

Harnessing nanoparticles for immune modulation

DR Getts, LD Shea, SD Miller, NJC King - Trends in immunology, 2015 - cell.com
Recent approaches using nanoparticles engineered for immune regulation have yielded
promising results in preclinical models of disease. The number of nanoparticle therapies is …

Nanotechnology-based siRNA delivery strategies for treatment of triple negative breast cancer

R Chadar, P Kesharwani - International Journal of Pharmaceutics, 2021 - Elsevier
Triple negative breast cancer (TNBC) is a subtype of breast cancer characterized by
absence of estrogen (ER) receptor, progesterone (PR) receptor, and human epidermal …

Secondary structure of corona proteins determines the cell surface receptors used by nanoparticles

CC Fleischer, CK Payne - The Journal of Physical Chemistry B, 2014 - ACS Publications
Nanoparticles used for biological and biomedical applications encounter a host of
extracellular proteins. These proteins rapidly adsorb onto the nanoparticle surface, creating …

Glioma‐targeted delivery of a theranostic liposome integrated with quantum dots, superparamagnetic iron oxide, and cilengitide for dual‐imaging guiding cancer …

HL Xu, JJ Yang, DL ZhuGe, MT Lin… - Advanced …, 2018 - Wiley Online Library
Herein, a theranostic liposome (QSC‐Lip) integrated with superparamagnetic iron oxide
nanoparticles (SPIONs) and quantum dots (QDs) and cilengitide (CGT) into one platform is …