How fast can a protein possibly fold? This question has stimulated experimentalists to seek
fast folding proteins and to engineer them to fold even faster. Proteins folding at or near the …

▪ Abstract This review describes how kinetic experiments using techniques with dramatically
improved time resolution have contributed to understanding mechanisms in protein folding …

The ensemble folding of two 21-residue α-helical peptides has been studied using all-atom
simulations under several variants of the AMBER potential in explicit solvent using a global …

We present a new approach that combines electronic structure methods and molecular
dynamics simulations to investigate the infrared spectroscopy of condensed phase systems …

A solvation term based on the solvent accessible surface area (SASA) is combined with the
CHARMM polar hydrogen force field for the efficient simulation of peptides and small …

1.1. Protein Folding Problem An understanding of the mechanism (s) of protein folding,
whereby the ribosome synthesized biopolymer folds into its native protein, is arguably one of …

This review of Raman spectroscopy covers the two-year period from late 1997 through late
1999. The previous two-year period has been comprehensively reviewed (1). There …

Poly (N-isopropylacrylamide)(PNIPAM) is the premier example of a macromolecule that
undergoes a hydrophobic collapse when heated above its lower critical solution …

Raman optical activity (ROA) measures vibrational optical activity by means of a small
difference in the intensity of Raman scattering from chiral molecules in right and left …

The helix-coil transition kinetics of an α-helical peptide were investigated by time-resolved
infrared spectroscopy coupled with laser-induced temperature-jump initiation method …