BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

Mitochondria are structurally and functionally distinct organelles that produce adenosine
triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to …

Mapping gene networks requires large amounts of transcriptomic data to learn the
connections between genes, which impedes discoveries in settings with limited data …

To predict the tropism of human coronaviruses, we profile 28 SARS-CoV-2 and coronavirus-
associated receptors and factors (SCARFs) using single-cell transcriptomics across various …

Clinical efficacy of treatments against non-obstructive azoospermia (NOA), which affects 1%
of men, are currently limited by the incomplete understanding of NOA pathogenesis and …

Aging men display reduced reproductive health; however, testis aging is poorly understood
at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over …

The human testis undergoes dramatic developmental and structural changes during
puberty, including proliferation and maturation of somatic niche cells, and the onset of …

Spermatogenesis is a highly regulated process that produces sperm to transmit genetic
information to the next generation. Although extensively studied in mice, our current …

Objective Effects of the diet-induced gut microbiota dysbiosis reach far beyond the gut. We
aim to uncover the direct evidence involving the gut–testis axis in the aetiology of impaired …

Human spermatogenesis is a highly ordered process; however, the roles of DNA
methylation and chromatin accessibility in this process remain largely unknown. Here by …