Metabolomics in NEC: an updated review

A Bosco, C Piu, ME Picciau, R Pintus, V Fanos, A Dessì - Metabolites, 2023 - mdpi.com
Necrotizing enterocolitis (NEC) represents the most common and lethal acute
gastrointestinal emergency of newborns, mainly affecting those born prematurely. It can lead …

Recent Progress in Human Milk Oligosaccharides and Its Antiviral Efficacy

Y Chen, Z Chen, Y Zhu, Y Wen, C Zhao… - Journal of Agricultural …, 2024 - ACS Publications
Gastrointestinal (GI)-associated viruses, including rotavirus (RV), norovirus (NV), and
enterovirus, usually invade host cells, transmit, and mutate their genetic information …

Fecal microbiota and volatile metabolome pattern alterations precede late-onset meningitis in preterm neonates

NM Frerichs, N Deianova… - The Journal of …, 2024 - academic.oup.com
Objective The fecal microbiota and metabolome are hypothesized to be altered before late-
onset neonatal meningitis (LOM), in analogy to late-onset sepsis (LOS). The present study …

Bidirectional regulation effect of rhubarb as laxative and astringent by metabolomics studies

P Zhou, J Zhang, Y Xu, P Zhang, Z Zhang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Rhubarb, a prominent traditional Chinese medicine, has
been employed as a potent laxative for centuries and garnered particular popularity among …

Succinate aggravates intestinal injury in mice with necrotizing enterocolitis

XL Yan, XC Liu, YN Zhang, TT Du, Q Ai… - Frontiers in Cellular …, 2022 - frontiersin.org
Background Necrotizing enterocolitis (NEC) is the most prevalent gastrointestinal disorder
that predominantly threatens preterm newborns. Succinate is an emerging metabolic …

Bovine colostrum prevents formula-induced gut microbiota dysbiosis in preterm pigs

L Yang, Y Hui, T Thymann, DS Nielsen, PP Jiang… - Pediatric …, 2024 - nature.com
Background Preterm birth and formula feeding increase the risk of necrotizing enterocolitis
(NEC), a gut inflammatory disease known to be associated with gut microbiota (GM) …

Metabolomics reveals changes in levels of fecal branched chain amino acids and organic acids in very preterm infants fed human milk fortified with bovine colostrum

Y Ye, L Yang, PP Jiang, PT Sangild, Y Hui, DS Nielsen… - Clinical Nutrition, 2024 - Elsevier
Background & aims Human milk is the optimal diet for very preterm infants (VPIs), but it
requires nutrient fortification to support growth. Bovine colostrum (BC), rich in intact proteins …

Therapeutic potential of human breast milk-derived exosomes in necrotizing enterocolitis

SJ Di, X Cui, TJ Liu, YY Shi - Molecular Medicine, 2024 - Springer
Necrotizing enterocolitis (NEC) is a severe inflammatory and necrotizing disease of the
intestine that primarily affects the neonates, particularly premature infants. It has a high …

Human milk oligosaccharides: bridging the gap in intestinal microbiota between mothers and infants

W Sun, L Tao, C Qian, P Xue, S Du… - Frontiers in Cellular and …, 2025 - frontiersin.org
Breast milk is an essential source of infant nutrition. It is also a vital determinant of the
structure and function of the infant intestinal microbial community, and it connects the mother …

Nutrition, Metabolites, and Human Health

C Papandreou - Nutrients, 2023 - mdpi.com
The field of metabolomics and related “omics” techniques allows for the identification of a
vast array of molecules within biospecimens. Their integration into nutritional studies may …