Functions of viroporins in the viral life cycle and their regulation of host cell responses

X Xia, A Cheng, M Wang, X Ou, D Sun, S Mao… - Frontiers in …, 2022 - frontiersin.org
Viroporins are virally encoded transmembrane proteins that are essential for viral
pathogenicity and can participate in various stages of the viral life cycle, thereby promoting …

Heterocyclic inhibitors of viroporins in the design of antiviral compounds

VA Shiryaev, YN Klimochkin - Chemistry of heterocyclic compounds, 2020 - Springer
Ion channels of viruses (viroporins) represent a common type of protein targets for drugs.
The relative simplicity of channel architecture allows convenient computational modeling …

Exploring the mechanism of photosensitizer conjugation on membrane perturbation of antimicrobial peptide: A multiscale molecular simulation study

Y Liu, M Song, J Wu, S Xie, Y Zhou, L Liu… - International Journal of …, 2023 - Elsevier
Antimicrobial peptides (AMPs) exert their biological functions by perturbation with cellular
membrane. Conjugation of AMPs with photosensitizer (PS) is a promising strategy for …

Molecular mechanisms of pore formation and membrane disruption by the antimicrobial lantibiotic peptide Mutacin 1140

R Pokhrel, N Bhattarai, P Baral, BS Gerstman… - Physical Chemistry …, 2019 - pubs.rsc.org
The emergence of antibiotic-resistance is a major concern to global human health and
identification of novel antibiotics is critical to mitigate the threat. Mutacin 1140 (MU1140) is a …

Lipid II binding and transmembrane properties of various antimicrobial lanthipeptides

R Pokhrel, N Bhattarai, P Baral… - Journal of Chemical …, 2021 - ACS Publications
There has been an alarming rise in antibacterial resistant infections in recent years due to
the widespread use of antibiotics, and there is a dire need for the development of new …

Cell Membrane Perforation: Patterns, Mechanisms and Functions

X Zhu, Z Shi, Y Mao, U Lächelt, R Huang - Small, 2024 - Wiley Online Library
Cell membrane is crucial for the cellular activities, and any disruption to it may affect the
cells. It is demonstrated that cell membrane perforation is associated with some biological …

Effect of cholesterol on the membrane partitioning dynamics of hepatitis A virus-2B peptide

S Sikdar, M Banerjee, S Vemparala - Soft Matter, 2021 - pubs.rsc.org
Understanding viral peptide detection and partitioning and the subsequent host membrane
composition-based response is essential for gaining insights into the viral mechanism. Here …

Гетероциклические ингибиторы виропоринов в дизайне антивирусных соединений

ВА Ширяев, ЮН Климочкин - Chemistry of Heterocyclic Compounds, 2020 - 5.179.29.131
Ion channels of viruses (viroporins) represent a common type of protein targets for drugs.
The relative simplicity of channel architecture allows convenient computational modeling …

Structural insights into the repair mechanism of AGT for methyl-induced DNA damage

RP Koirala, R Pokhrel, P Baral, PB Tiwari… - Biological …, 2021 - degruyter.com
Methylation induced DNA base-pairing damage is one of the major causes of cancer. O6-
alkylguanine-DNA alkyltransferase (AGT) is considered a demethylation agent of the …

Filoviridae: Insights into Immune Responses to Ebolavirus

B Brown, C Imarogbe, T Gravier, I Fricke… - Available at SSRN …, 2023 - papers.ssrn.com
Ebola virus is a zoonotic virus comprised of 6 different species designated within the family
Filo-viridae and genus Ebolavirus. The first recorded outbreak of an Ebola virus (EBOV) was …