Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Malaria is a major disease of humans caused by protozoan parasites from the genus
Plasmodium. It has a complex life cycle; however, asexual parasite infection within the blood …

The most severe form of malaria is caused by Plasmodium falciparum. These parasites
invade human erythrocytes, and an essential step in this process involves the ligand PfRh5 …

During blood stage Plasmodium falciparum infection, merozoites invade uninfected
erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand …

Plasmodium falciparum parasites in the merozoite stage invade human erythrocytes and
cause malaria. Invasion requires multiple interactions between merozoite ligands and …

Apicomplexan parasites exhibit tremendous diversity in much of their fundamental cell
biology, but study of these organisms using light microscopy is often hindered by their small …

Erythrocyte invasion by the merozoite is an obligatory stage in Plasmodium parasite
infection and essential to malaria disease progression. Attempts to study this process have …

Obligate intracellular Apicomplexa parasites share a unique invasion mechanism involving
a tight interaction between the host cell and the parasite surfaces called the moving junction …

Most Apicomplexa are obligate intracellular parasites and many are important pathogens of
human and domestic animals. For a successful cell invasion, they rely on their own motility …

All the symptoms and pathology of malaria are caused by the intraerythrocytic stages of the
Plasmodium parasite life cycle. Because Plasmodium parasites cannot replicate outside a …