Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

E-cadherin is a major homophilic cell-cell adhesion molecule that inhibits motility of
individual cells on matrix. However, its contribution to migration of cells through cell-rich …

A growing number of studies are revealing that cells can send and receive information by
controlling the temporal behavior (dynamics) of their signaling molecules. In this Review, we …

Fluorescence microscopy provides an efficient and unique approach to study fixed and
living cells because of its versatility, specificity, and high sensitivity. Fluorescence …

Cell proliferation is a fundamental requirement for organismal development and
homeostasis. The mammalian cell division cycle is tightly controlled to ensure complete and …

For a cell to move forward it must convert chemical energy into mechanical propulsion.
Force produced by actin polymerization can generate traction across the plasma membrane …

It is generally believed that cytoskeletal activities drive random cell migration, whereas
signal transduction events initiated by receptors regulate the cytoskeleton to guide cells …

Every cell biologist who has used a microscope knows that single cells in a population
display variable behavior. Although heterogeneity between single cells is obvious in tissues …

Genetically encoded fluorescent biosensors are powerful tools for monitoring biochemical
activities in live cells, but their multiplexing capacity is limited by the available spectral …