[HTML][HTML] Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives
The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …
[HTML][HTML] Stem cell treatment of degenerative eye disease
Stem cell therapies are being explored extensively as treatments for degenerative eye
disease, either for replacing lost neurons, restoring neural circuits or, based on more recent …
disease, either for replacing lost neurons, restoring neural circuits or, based on more recent …
Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors
RA Pearson, A Gonzalez-Cordero, EL West… - Nature …, 2016 - nature.com
Photoreceptor replacement by transplantation is proposed as a treatment for blindness.
Transplantation of healthy photoreceptor precursor cells into diseased murine eyes leads to …
Transplantation of healthy photoreceptor precursor cells into diseased murine eyes leads to …
Recapitulation of human retinal development from human pluripotent stem cells generates transplantable populations of cone photoreceptors
A Gonzalez-Cordero, K Kruczek, A Naeem… - Stem cell reports, 2017 - cell.com
Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent
stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited …
stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited …
Restoration of vision after transplantation of photoreceptors
Cell transplantation is a potential strategy for treating blindness caused by the loss of
photoreceptors. Although transplanted rod-precursor cells are able to migrate into the adult …
photoreceptors. Although transplanted rod-precursor cells are able to migrate into the adult …
Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina
A Gonzalez-Cordero, EL West, RA Pearson… - Nature …, 2013 - nature.com
Irreversible blindness caused by loss of photoreceptors may be amenable to cell therapy.
We previously demonstrated retinal repair and restoration of vision through transplantation …
We previously demonstrated retinal repair and restoration of vision through transplantation …
Regenerative therapies for central nervous system diseases: a biomaterials approach
The central nervous system (CNS) has a limited capacity to spontaneously regenerate
following traumatic injury or disease, requiring innovative strategies to promote tissue and …
following traumatic injury or disease, requiring innovative strategies to promote tissue and …
In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction
The use of stem-cell therapy to treat retinal degeneration holds great promise. However,
definitive methods of retinal differentiation that do not depend on recombinant proteins …
definitive methods of retinal differentiation that do not depend on recombinant proteins …
A hyaluronan-based injectable hydrogel improves the survival and integration of stem cell progeny following transplantation
The utility of stem cells and their progeny in adult transplantation models has been limited by
poor survival and integration. We designed an injectable and bioresorbable hydrogel blend …
poor survival and integration. We designed an injectable and bioresorbable hydrogel blend …
Repair of the degenerate retina by photoreceptor transplantation
AC Barber, C Hippert, Y Duran… - Proceedings of the …, 2013 - National Acad Sciences
Despite different aetiologies, age-related macular degeneration and most inherited retinal
disorders culminate in the same final common pathway, the loss of photoreceptors. There …
disorders culminate in the same final common pathway, the loss of photoreceptors. There …